Space of Disse

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Sinusoid of a rat liver with fenestrated endothelial cells. Fenestrae are approx 100 nm diameter, and the sinusoidal width 5 µm. Scanning electron micrograph by Robin Fraser, University of Otago.
Sinusoid of a rat liver with fenestrated endothelial cells. Fenestrae are approx 100 nm diameter, and the sinusoidal width 5 µm. Scanning electron micrograph by Robin Fraser, University of Otago.

The space of Disse (or perisinusoidal space) is a location in the liver between a hepatocyte and a sinusoid. It contains the interstitial fluid. Microvilli of hepatocytes extend into this space.

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Anatomy of torso, digestive system: Digestive glands

Pancreas (Tail, Body, Head, Islets of Langerhans) - Gallbladder - Liver (Hepatocyte, Space of Disse, Kupffer cell, Liver sinusoid, Hepatic stellate cell, Hepatic lobule)

Bile ducts: (Bile canaliculus, Common hepatic duct, Cystic duct, Common bile duct) - Pancreatic duct - Hepatopancreatic ampulla

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