Sp1
From Wikipedia, the free encyclopedia
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Sp1 transcription factor
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| Identifiers | |
| Symbol | SP1 |
| HUGO | 11205 |
| Entrez | 6667 |
| OMIM | 189906 |
| RefSeq | NM_138473 |
| UniProt | P08047 |
| Other data | |
| Locus | Chr. 12 q13.1 |
Sp1 is a human transcription factor involved in gene expression in the early development of an organism. The protein is 785 amino acids long, with a molecular weight of 95 kDA. The full protein sequence can be found banked in the NCBI homepage, with the accession number NP_612482. The SP1 transcription factor contains a zinc finger protein motif, by which it binds directly to DNA and enhances gene transcription. Its zinc fingers are of the Cys2/His2 type and binds the consensus sequence 5'-(G/T)GGGCGG(G/A)(G/A)(C/T)-3' (GC box element). It was discovered in 1983 and has since been modified to form Sp1C, which has a zinc finger protein DNA binding domain.
In the SV40 virus, Sp1 binds to the GC boxes in the regulatory region(RR) of the genome.
[edit] References
- Dreier B, Beerli R, Segal D, Flippin J, Barbas C (2001). "Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors". J Biol Chem 276 (31): 29466-78. PMID 11340073.
[edit] External links
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CAP - CBF - E2F - KlF - Nanog - NF-kB - Oct-4 - P300/CBP - PIT-1 - Rho/Sigma - R-SMAD - Sox2 - Sp1 - STAT (STAT1, STAT3, STAT5)
Basic-helix-loop-helix: AhR - HIF - MYC - Twist - Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6)
Basic leucine zipper: C/EBP - CREB - AP-1
Basic helix-loop-helix leucine zipper: MITF - SREBP
Nuclear receptors: subfamily 1 (Thyroid hormone, RAR, PPAR, LXR, FXR, Calcitriol, PXR, CAR) - subfamily 2 (HNF4, RXR) - subfamily 3/Steroid hormone (Estrogen, Estrogen related, Glucocorticoid, Mineralocorticoid, Progesterone, Androgen) - subfamily 0 (NR0B1)
