Son of Sevenless
From Wikipedia, the free encyclopedia
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son of sevenless homolog 1 (Drosophila)
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| Identifiers | |
| Symbol | SOS1 GINGF |
| HUGO | 11187 |
| Entrez | 6654 |
| OMIM | 182530 |
| RefSeq | NM_005633 |
| UniProt | Q07889 |
| Other data | |
| Locus | Chr. 2 p21 |
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son of sevenless homolog 2 (Drosophila)
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| Identifiers | |
| Symbol | SOS2 |
| HUGO | 11188 |
| Entrez | 6655 |
| OMIM | 601247 |
| RefSeq | NM_006939 |
| UniProt | Q07890 |
| Other data | |
| Locus | Chr. 14 q21 |
SOS (Son of Sevenless) is gene encoding a Guanine Nucleotide Exchange Factor that acts on Ras-GTPases. SOS is an orthologue of a gene originally found in Drosophila that was found to be necessary for Ras/MAP kinase pathway activation during the development of the ultraviolet light sensitive R7 photoreceptor of the fly's compound eye[1] [2] . The mammalian homologue similarly functions downstream of many growth factor and adhesion receptors. Ras-GTPases act as molecular switches that bind to downstream effectors, such as the protein kinase c-Raf, and localizes them to the membrane resulting in their activation. Ras-GTPases are considered inactive when bound to Guanosine diphosphate (GDP) and active when bond to Guanosine triphosphate (GTP). As the name implies, Ras-GTPases possess intrinsic enzymatic activity that converts GTP to GDP plus phosphate. Thus, upon binding to GTP, the duration of Ras-GTPase activity is limited by the rate at which it hydrolyzes its bound GTP to GDP. SOS (and other guanine nucleotide exchange factors) act by binding Ras-GTPases and forcing them to release of their bound nucleotide (usually GDP). Once released from SOS, the Ras-GTPase quickly binds fresh guanine nucleotide from the cytosol. Since GTP is roughly ten times more abundant than GDP in the cytosol, this usually results in Ras activation. The normal rate of GTP hydrolysis can be increased by proteins of the RasGAP family, which bind to Ras and increase its catalytic rate by thousands of fold.
Mammals possess two SOS paralogues: SOS1 and SOS2.
[edit] Genetic Diseases Associated with SOS1
Dominant mutant alleles of SOS1 have recently been found to cause Noonan's Syndrome[3] and Hereditary Gingival Fibromatosis type 1[4]. Noonan syndrome has also been shown to be caused by mutations in KRAS and PTPN11 genes[5]. A common feature of these genes is that their products have all been strongly implicated as positive regulators of the Ras/MAP kinase signal transduction pathway. Therefore it is thought that dysregulation of this pathway during development is responsible for many of the clinical features of this syndrome[6]. Noonan syndrome mutations in SOS1 are distributed in clusters positioned throughout the SOS1 coding region. Biochemically, these mutations have been shown to similarly effect aberrant activation of the catalytic domain towards Ras-GTPases. This may be explained because the SOS1 protein adopts an auto-inhibited conformation dependent on multiple domain-to-domain interactions that cooperate to block access of the SOS1 catalytic core to its Ras-GTPase targets[7]. The mutations that cause Noonan syndrome thus appear to perturb intramolecular interactions necessary for SOS1 auto-inhibition. In this way these mutations are thought to create SOS1 alleles encoding hyper-activated and dysregulated variants of the protein.
[edit] References
- ^ Simon M, et al. Cell 1993;9:169-77
- ^ Nimnual A, Bar-Sagi D (2002). "The two hats of SOS". Sci STKE 2002 (145): PE36. PubMed.
- ^ Roberts AE, et al. Nature Genetics Published online: 3 December 2006
- ^ Hart TC Am. J. Hum. Genet. 2002; 70:943–954
- ^ Tartaglia M, et al. Nature Genetics 2001;29:465-468
- ^ Bentires-Alj M, et al. Nat Med. 2006; 12:283-285
- ^ Sondermann, et al. Cell 2004; 119:393-405
