Talk:Sodium valproate
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Removed the sentence 'Sodium valproate may also be used as an antidepressant, though this is not its usual indication.', as far as I can see there is a small amount of evidence saying it may have antidepressant effects, but this is not the same as using it as an antidepressant. Maybe it would be better to leave this out until someone writes a more detailed 'mechanism of action' type bit, and the link to the paper showing possibility of antidepressant action. May make a start if I have time.Berry 08:45, 27 April 2006 (UTC)
- The above sentence was added by 143.239.68.37 and I regret not immediately removing it. You may be interested in reading some Cochrane reviews rather than just plucking papers at random. See this and this for example.
- My preference would be to indicate that a drug is used off-label or is being researched for if there are papers discussing "uses" such as this. And only state that it is "used" for something if it actually is licenced and you can point at the BNF, etc as proof that doctors really are using it as such. For historical uses, Google Books can usually turn up some textbooks to use for sources. My own pet peeve is that loads of drugs have some anticonvulsant effect, but rather few are actually used for the purpose.
The following was added to the article -
[edit] News about action taken against this drug in UK
Template:News about action taken against this drug in UK
I am not convinced this belongs in the article as this is a very new story and the allegations have not been proven one way or the other. Certainly I seem to remember it is well known that some anticonvulsants cause birth defects and I am sure Sanofi made that perfectly clear in their PI, probably to avoid stories like this. A lot of the claims seem not to be due to birth defects but to the presence of so called autistic spectrum disorders and behavioural effects, don't get me started on the autism epidemic...this makes me think it may be difficult to prove a case against the company. The trial date is set for 2008 so I think if relevant any information should be added then (if anyone is still around!) Basically I think this is a somewhat biased view from 140 families which are extrapolating their data to the whole of the UK but judgement should be reserved until the trial date. Berry 09:46, 26 May 2006 (UTC)
[edit] Use of Sodium Valproate for prevention of psychoses
It seems that Sodium Valproate has recently been discovered to be helpful in preventing relapses fromm certain psychiatric disorders, specifically psychoses.-posted 13:15, 1 August 2006 by 129.35.231.17-
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- Could you please provide a source of this information and sign your posts? Valproate is in deed given by certain psychotic states, but mainly to stabilise the mood and/or supress mania, and/or epileptic seizures. An antipsychotic effect is not known, as far as I know.--Spiperon 01:04, 22 October 2006 (UTC)
