Sodium valproate

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Main article: Valproic acid


Sodium valproate
Systematic (IUPAC) name
sodium 2-propylpentanoate
Identifiers
CAS number	1069-66-5
ATC code	N03AG01
PubChem	14047
Chemical data
Formula	C₈H₁₅Na O₂
Mol. mass	166.20
Pharmacokinetic data
Bioavailability	?
Protein binding	90-95%
Metabolism	75% by CYP enzymes
Half life	9 -18 hours
Excretion	20% excreted as glucuronide
Therapeutic considerations
Pregnancy cat.	D(AU) D(US)
Legal status	POM(UK) ℞-only(US)
Routes	oral, i.v.

Sodium valproate (INN) or valproate sodium (USAN) is the sodium salt of valproic acid and is an anticonvulsant used in the treatment of epilepsy; as well as being used as a mood stabilizer. The intravenous formulations are used when oral administration is not possible.

1 Formulations
2 See also
3 External links

[edit] Formulations

[edit] US

Intravenous injection – Depacon^® by Abbott Laboratories.
Syrup – Depakene by Abbott Laboratories. (Note Depakene capsules are valproic acid).

[edit] UK & Australia

Tablets – Orlept^® by Wockhardt and Epilim^® by Sanofi-Aventis.
Oral solution – Orlept^® Sugar Free by Wockhardt and Epilim^® by Sanofi-Aventis.
Syrup – Epilim^® by Sanofi-Aventis.
Intravenous injection – Epilim^® Intravenous by Sanofi-Aventis.
Extended release tablets – Epilim Chrono^® by Sanofi-Aventis. A combination of sodium valproate and valproic acid in a 2.3:1 ratio.
Enteric-coated tablets – Epilim^® EC200 by Sanofi-synthelabo. A 200mg Sodium Valporate enteric-coated tablet.

[edit] Germany, Switzerland, Norway

Tablets – Orfiril^® by Desitin Pharmaceuticals
Intravenous injection – Orfiril^® IV by Desitin Pharmaceuticals

[edit] South Africa

Syrup – Convulex^® by Byk Madaus

[edit] Canada

Intravenous injection – Epival^® or Epiject^® by Abbott Laboratories.
Syrup – Depakene^® by Abbott Laboratories. Generic formulations include Apo-Valproic and ratio-Valproic.