Image:Signal transduction pathways.jpg

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--> = stimulation --| = inhibition

Pathways involved:

Growth factors

-->RTK Receptor tyrosine kinase

-->Grb2, SOS Son of Sevenless

-->Ras

-->Raf

-->MEK MAPK/ERK kinase

-->MAPK --> Jun, Mad:Max

-->ERK

-->Fos C-fos

MEK --> MEKK

--> Myc:Max

PLC phospholipase C

-->PKC protein kinase c

-->Raf

Ras

-->Cdc42

-->Rac

-->Rho

Mos c-Mos

-->MEK MAPK/ERK kinase

ECM Extracellular matrix

-->Integrins

Integrins

-->Cdc42

-->PI3K

-->Rac

-->JNK

-->Jun

Integrins

-->FAK Src

-->Cas CRK-associated substrate

-->CRK

Integrins

-->Fyn Shc Src homology 2 domain-containing

-->Ras

MKKs

-->JNKs

Hormones

e.g.

bombesin

-->7TM-receptor

-->G-prot G-protein

-->Ras, PI3K, Ad cycl Adenylate cyclase

-->PKA protein kinase A

-->CREB

e.g.

estrogen

-->NHR

Survival factors

e.g.

IGF1

-->RTK Receptor tyrosine kinase

-->PI3K

-->PKC Protein kinase C

-->NF-kB

PI3K

-->Akt

-->Akka Akk-alpha

-->IκB

-->NF-kB

Cytokines

-->Cytokine R Cytokine-Receptor

-->Jaks

-->Stats

-->Bcl XL

--|cytochrome c

Abnormality sensor

e.g.

Bim

-->Mt Mitochondria

-->cytochrome c

-->casp9 caspase 9

-->apoptosis

Akt

--|Bad Bcl-2-associated death promoter

--> Mt Mitochondria

Decoy Receptor

--|Death factors

e.g.

FasL Fas ligand

-->Fas

-->FADD

-->caspase 8

-->apoptosis

caspase 8

-->Bld

-->Mt Mitochondria

-->apoptosis

FAP Fas-associated phosphatase

--|Fas

Changes in gene expression

-->ARF

--|MDM2

--|p53

-->Bax

-->Mt Mitochondria

-->apoptosis

Antigrowth factors

e.g.

TGFβ

-->TGFβR TGFβ receptors

-->Smads

-->p15, p27]], p21

p15

--|cycl D Cyclin D CDK4 Cyclin-dependent kinase 4

--|Rb Retinoblastoma protein

--|E2F

p21

--|cycl E Cyclin E CDK2 Cyclin-dependent kinase 2

HPVE7 --|Rb Retinoblastoma protein

Hedgehog

-->Patched

-->Smoothened

-->Gil

-->Changes in gene expression

Sufu

--> Gil

Wnt

-->Frizzled

-->Dishevelled

-->GSK-3β

-->APC

-->β-catenin

β-catenin + TCF T-cell factor

--> Gene expression

Painted by Mikael Häggström

[edit] References

Molecular cell biology. Lodish, Harvey F. 5. ed. : - New York : W. H. Freeman and Co., 2003, 973 s. b ill. ISBN: 0-7167-4366-3

[edit] Licensing

File history

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• (del) (cur) 23:11, 22 March 2007 . . Roadnottaken (Talk | contribs) . . 1858×1364 (870,309 bytes) (updated version of old figure. self-made in illustrator.)
• (del) (rev) 23:09, 22 March 2007 . . Roadnottaken (Talk | contribs) . . 1858×1364 (1,475,614 bytes) (updated version of previous figure. self-made in illustrator.)
• (del) (rev) 23:08, 22 March 2007 . . Roadnottaken (Talk | contribs) . . 1858×1364 (1,475,614 bytes) (updated version of previous figure. self-made in Illustrator.)
• (del) (rev) 16:01, 13 March 2007 . . Mortsggah (Talk | contribs) . . 1173×711 (175,343 bytes) (--> = stimulation --| = inhibition Pathways involved: Growth factors -->RTK Receptor tyrosine kinase -->Grb2, SOS Son of Sevenless -->Ras -->Raf -->MEK MAPK/ERK kinase -->[[MAPK)

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File links

• Wnt signaling pathway
• NHR
• Bcl-xL
• C-Mos

Metadata

This file contains additional information, probably added from the digital camera or scanner used to create or digitize it. If the file has been modified from its original state, some details may not fully reflect the modified image.

Orientation	Normal
Horizontal resolution	150 dpi
Vertical resolution	150 dpi
Software used	Adobe Photoshop CS2 Windows
File change date and time	16:10, 22 March 2007
Color space	65535