Sharpless oxyamination
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The Sharpless oxyamination (often known as Sharpless aminohydroxylation) is the chemical reaction of alkenes with alkyl imido osmium compounds to form vicinal amino-alcohols. A comprehensive review of this reaction has been authored by McLeod et al in 2002, little further work has been conducted on this reaction since this time (as of Jan 2007).
Vicinal amino-alcohols are important products in organic synthesis and reoccuring pharmacophores in drug discovery.
[edit] References
- ^ Sharpless, K. B.; Patrick, D. W.; Truesdale, L. K.; Biller, S. A. J. Am. Chem. Soc. 1975, 97, 2305. (DOI:10.1021/ja00841a071)
- ^ Herranz, E.; Biller, S. A.; Sharpless, K. B. J. Am. Chem. Soc. 1978, 100, 3596-3598. (DOI:10.1021/ja00479a051)
- ^ Herranz, E.; Sharpless, K. B. Org. Syn., Coll. Vol. 7, p.375 (1990); Vol. 61, p.85 (1983). (Article)
- ^ Jennifer A. Bodkin and Malcolm D. McLeod, J. Chem. Soc., Perkin Trans. 1, 2002, 2733–2746 (DOI:10.1039/b111276g)
- ^ Bäckvall, J. E.; Oshima, K.; Palermo, R. E.; Sharpless, K. B. J. Org. Chem. 1979, 44, 1953. (DOI:10.1021/jo01326a013)
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