Shar Pei fever

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Shar Pei fever is a condition seen in Shar Peis characterized by recurring fever and swelling of the hocks. It is similar to familial Mediterranean fever in humans. The cause is unknown, but it is thought to be inherited.[1] Shar Pei fever can result in renal and liver failure through accumulation of amyloid in those organs (amyloidosis).

Affected Shar Peis have an elevated level of interleukin 6, and this leads to an accumulation of acute phase proteins in the body during the fevers. The acute phase proteins are broken down to form type AA amyloid, which deposits in the kidneys and less so in the liver, spleen, and gastrointestinal tract.[2] This eventually leads to kidney or liver failure by the age of six years.[1]

The symptoms of Shar Pei fever include fever, swelling, and pain in the hocks that usually resolves within two days. The symptoms can be treated with NSAIDs such as aspirin. Kidney and liver failure can not be treated except by the conventional manner usually used for those diseases. Prevention of amyloidosis is sometimes used in dogs with recurring episodes of Shar Pei fever. Colchicine and dimethyl sulfoxide are most commonly used.[1] Dogs taking colchicine must be monitored closely for signs of bone marrow disease. The prognosis is guarded for Shar Peis that develop amyloidosis.

[edit] References

  1. ^ a b c Ettinger, Stephen J.;Feldman, Edward C. (1995). Textbook of Veterinary Internal Medicine, 4th ed., W.B. Saunders Company. ISBN 0-7216-6795-3. 
  2. ^ Tellier L (2001). "Immune-mediated vasculitis in a shar-pei with swollen hock syndrome". Can Vet J 42 (2): 137-9. PMID 11272460. 
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