Talk:Sarcoidosis
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I had a question concerning Sarcoidosis. My mom has it and she has had a rash that itches very bad for almost four years. What can she do to help with the rash itching so much? Is this a caused by sarcoidosis?
- Depends a lot what type of rash, but sarcoidosis frequently causes rash. It responds to steroids and, oddly, some types of antibiotics (minocycline). JFW | T@lk
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[edit] New edits
To the anonymous editor who has been working on this article: when you made an edit last week I converted your hyperlinks into proper scientific references. I was hoping you'd continue in that vein. Your expertise is much appreciated. JFW | T@lk 07:32, 8 Jun 2005 (UTC)
- Okay, I've structured this. The link to the Marshall study was incorrect and this is not clinical practice anyway (how do you control vitamin D levels?)
- Instead of citing lots of original studies, I would recommend focussing on reviews to decrease the citation load. An exception is probably classical references or hallmark studies. JFW | T@lk 11:59, 8 Jun 2005 (UTC)
I have this disease. It almost made me loose all function waste down. With treatment of prednizon I can atleast use a walker now. I break out some times, But I just stay extra clean. As far as the rash not shure.
[edit] JFW, here are some citations to fill the void
Dear JFW I stumbled across this page while exploring Google's Sarcoidosis rankings
I note your comments: "Okay, I've structured this. The link to the Marshall study was incorrect and this is not clinical practice anyway (how do you control vitamin D levels?) Instead of citing lots of original studies, I would recommend focussing on reviews to decrease the citation load."
I would have appreciated your contacting me before using my name in public in this way. My email is on all our peer-reviewed papers.
If you are looking for reviews, then I would suggest the following for an explanation of not only how you control the D metabolism, but also its effects on Th1 disease:- Marshall TG, Marshall FE: Sarcoidosis succumbs to antibiotics - implications for autoimmune disease. Autoimmunity Reviews,2004; 3(4):295-3001. Available from URL http://dx.doi.org/10.1016/j.autrev.2003.10.001 FullText at author website http://yarcrip.com/sarcoidosissuccumbs-preprint.htm
If you read Russian you might also cite a, more detailed, invited paper to a print journal:- Marshall TG, Fenter B, Marshall FE: Antibacterial Therapy Induces Remission in Sarcoidosis. Herald MKDTS 2004g; Volume III: Release 1. (The Journal of the Interregional Clinical-Diagnostic Center, Kazan, Invited paper, Special issue on Sarcoidosis. Published in Russian translation). ISSN: 1726-6149 Available from URL http://www.icdc.ru/home.nsf/ae6ba61f2370d2c3c3256f4800499282/7c4adb204d59034bc3256f660035e4ce?OpenDocument
Another citation to a print publication is Marshall TG, Marshall FE: Sarcoidosis succumbs to antibiotics - implications for autoimmune disease. Autoimmunity Reviews,2004; Suppl 2:55 (Abstracts of 4th International Congress on Autoimmunity)
I know that a lot of our work may seem counter-intuitive to a practioner, as it does require a fairly comprehensive understanding of molecular medicine to untangle the decades of poorly performed epidemiological studies upon which the myths which have perpetuated these idiopathic diseases are based.
Anyway, feel free to contact me at any time
Sincerely, Trevor (16 June 2005)
Including any research by Trevor Marshall is dangerous. I have this disease, and almost fell for his protocol. He is not a PhD, and his doctorate is in elctronic engineering. His protocol has never been published or reviewed. [[1]] 71.252.139.254 01:24, 13 September 2006 (UTC)Gnaget
I also removed the reference to autoimunity research foundation as them being a sponsor is irrelevant. Them being a sponsor only gives the impression of FDA acceptance of Marshall's protocol, when in fact there is none. 71.252.139.254 01:40, 13 September 2006 (UTC) Gnaget
- I agree. I read with great worry the article about Trevor Marshall on Wikipedia, which seems to me has been written by just one or two people, to glorify the achievements of that man. To me, such contributions undermine the value of Wikipedia.
- I have neither time nor nerve to argue with this man but many contributions on the net cast doubt on this person, most notably this [[2]] contribution by Peter Vanlandschoot. A less authoritative but very interesting website provides a compilation of uncertainties [[3]]. Savisha 08:40, 10 December 2006 (UTC)savisha
[edit] characterization of sarcoid
I removed the reference to sarcoid as an autoimmune disease. The reason is 1. the cause hasn't be exactly determined and 2.research seems to point towards sarcoid being caused by the immune system developing an abnormal response to an exposure - this may be viral, baterial, or environment apparently. Obviously, there is a genetic component which confers certain people with a higher risk of developing this response. If this is true, then, sarcoid is not an autoimmune diease because the body is not attacking its own tissues directly. Rather it is directing itself against a foreign antigen, but for some reason not clear to me, responds unusually and causes indirect damage to the hosts own tissues. Also the pathophys part is too narrow. It cites one article that is way out there compared to the vast majority of the literature on sarcoidosis. I'll likely revise it soon to more closely reflect more accept thoughts regarding pathophysiolgy and etiology. I'm not saying what is there is wrong, its just too focused and ignores the prevailing theories which have much more evidence to back them up. -sph (23 July 2005)
I believe at this point it is pretty well accepted in the medical community as being an autoimmune disorder. If research finds enough evidence that it is not, it will be changed, but it is best for WP to be on the heels of the research, and not leading it 71.252.139.254 01:51, 13 September 2006 (UTC) Gnaget
As a member of the medical community and someone who has done talks on the topic at conferences, I can tell you that you are wrong. Read any peer reviewed article on the pathophys of sarcoid; not one will call it an autoimmune disease. Please read my explaination above. -sph
[edit] sarcoidosis
hi, my husband, 51 yrs., recently diagnosed with sarcoid. the involvement in the bones and marrow is such that the current doctor says he has "poor prognosis factors" due to the extenrt of the diasease and that she thinks he is "doing quite well for the shape he is in". she also mentioned mayo clinic due to the extreme involvement in the lungs, spinal column etc. he works outside on road construction..... she has perscribed 80 mg prednisone for 1 wl, then 70 2nd week then 60 for the remainder of a six month period plus bactrim, plus calcium, vit d and fosomax..... no one will say what the "poor prognosis factor" is. i have a call in to see if the dr thinks we whould go to mayo...... is there any medical person out there that can help us????? where should i write so someone can look at his test results etc.... he recentl;y had a kidney stone rem,oved... that is what started all this the er dr said he had cancer!!! we have been to like 8 different Drs. getting this diagnosis - bone marrow biopsy beint the last one because there is so much involvement in the spine they were afraid to call it sarc
thanks, Deb...... dshupak@msn.com
- Good day, Deb. I wish to point you towards Wikipedia:Medical disclaimer. While many Wikipedia writers are experts in their subject area, this is a publicly editable encyclopedia. As such, I recommend you discuss your husband's decision with a licensed medical doctor -- any person could post fictitious responses to you, and the information would be unreliable. I wish you and your husband the best.
[edit] References
Can we add a layman's description to the first paragraph? I want to know what sarcoidosis is, but I don't know what a non-necrotising granuloma is. Also, shouldn't the cause be in the first paragraph as well?
[edit] Suggestions for the first paragraph
Can we add a layman's description to the first paragraph? I want to know what sarcoidosis is, but I don't know what a non-necrotising granuloma is. Also, shouldn't the cause be in the first paragraph as well? --65.91.102.204 16:26, 20 March 2007 (UTC)
