Talk:S-Adenosyl methionine
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[edit] Merge from S-adenosylmethionine
I have added a mergefrom. Shouldn't be hard to do! --Slashme 11:33, 28 November 2005 (UTC)
- Done Kcordina 09:22, 16 March 2006 (UTC)
I've yet to read a tutorial on how to redirect a query to a specific page, so I was hoping that someone could assist me. SAMe is also known as 'ademetionine' - and searching for it should redirect you to this article on SAMe - irrespective of whether 'ademetionine' is merely employed by supplement companies to sound pharmaceutical (I'm unclear about the legitimacy of the word) substantiate 15 Feb 2007
added a redirect --Substantiate 02:03, 17 February 2007 (UTC)
[edit] Cleanup
I will have a look at cleaning this up some time! --Slashme 11:33, 28 November 2005 (UTC)
I've made a start on cleaning this up, and will need to begin adding references. As you can tell, I'm better at the biochemistry side than the supplement section. --TimVickers 16:35, 25 June 2006 (UTC)
I added a reference from the Am J Psychiatry re depression efficacy --Substantiate 02:05, 17 February 2007 (UTC)
[edit] Misc
Sure I don't know how to add hyperlinking or add references that only authorized people may have access to. -RS
The comment below was copied from Talk:S-adenosylmethionine during merging. Kcordina 09:22, 16 March 2006 (UTC)
I'm pretty new to Wikipedia, but "being bold." I added the pharmocology stub tag to this article, in the hope that Wikipedians with relevant expertise will expand it. SAM-e is taken for depression and joint pains. It is prescribed in Europe, but can be purchased in the US over the counter in supplement stores. It is generally quite expensive. Because it has become a trendy anti-depressant (usually self-prescribed in the US), I feel that it is important to give people more information about this supplement. It has medical advocates, most notably Dr. Richard Brown (author of "Stop Depression Now"), but I have come across many articles advising caution, as long-term effects are not established. Of most concern is that the supplement breaks down to homocysteine, high levels of which are apparently sometimes indicative of (or causative??) of heart disease.
As with so many supplements, a Google search is flooded with very positive explanations of this supplement by companies selling it. The few negative articles are by medical experts who often seem to reject it reflexively, because its effectiveness has not yet been adequately researched. There is a real need for an objective, in-depth summary of how this supplement works, and what is known about its effectiveness and side effects.
I am not a medical or pharmacological expert, even remotely, so I labeled this a stub in hopes that someone who has expertise in a relevant field can expand it. (StrangeAttractor 15:47, 10 December 2005 (UTC))
Although this article and many others state that SAM-e is invoplved in the synthesis of dopamine and serotonin (others add epinephrine or norepinephrine), the metabolic pathway is not described, neither here nore under the articles refering to the respective neurotransmitters. Thye synthesis pathways for dopamine and serotonin which are given in their respective articles do not mention either SAM-e or methylation. I think it would be good to understand what role SAM-e plays in those synthesis paths, and especially whether it plays a role in the rate-limiting step. 66.245.159.152 20:49, 6 March 2007 (UTC)Andrew Hoerner
[edit] degradation and dosage
"SAM is still liable to degradation leading to distributors that may advertise a dose higher than what is actually being ingested." I'm not sure what this is saying. Are you saying the maker, for example, puts 400mg in the tablet and prints 400mg on the box and then you get 300mg due to degredation? (I just got Zentonil 400 for my dog today.) --Gbleem 20:45, 22 April 2006 (UTC)
- Yes. It appears that SAMe is somewhat difficult to make and has poor stability. Most articles suggest the blister packs and enteric coating to improve stability but I can not find any research to back this up. Some articles recommend against refrideration but the best article used it and documented the degradation with time.
- The various companies have developed newer salt forms but this may have been mainly an attempt to avoid other patents. I can find very little (almost no) information comparing off the shelf potency of various salt forms, their stability, and bioavailablity.
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- —Who123 17:41, 8 December 2006 (UTC)
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[edit] dosage
though i've yet to find a reliable source to site via internet, the therapeutic dose of SAMe is not usually 800-1600mg/day. in fact it is usually 200mg/day. 1600mg would be considered a very large dose. —The preceding unsigned comment was added by Harlequence (talk • contribs) 01:28, 17 January 2007 (UTC).
for depression, dosages in the range of 800 - 1600mg would be considered therapeutic. run a pubmed search and note the abstracts that used oral administration, i.e. Obstetrics and Gynecology Department, University La Sapienza School of Medicine, Rome, Italy.
S-adenosyl-L-methionine (SAMe) is a naturally occurring substance which is a major source of methyl groups in the brain and has been found in previous studies to be an effective antidepressant. The aim of this study was to assess the efficacy of oral SAMe in the treatment of depressed postmenopausal women in a 30-day double-blind placebo-controlled randomized trial. During the course of the study, 80 women, between the ages of 45 and 59, who were diagnosed as having DSM-III-R major depressive disorder or dysthymia between 6 and 36 months following either natural menopause or hysterectomy, underwent 1 week of single-blind placebo washout, followed by 30 days of double-blind treatment with either SAMe 1,600 mg/day or placebo. There was a significantly greater improvement in depressive symptoms in the group treated with SAMe compared to the placebo group from day 10 of the study. Side effects were mild and transient.
also, http://www.umm.edu/altmed/ConsSupplements/SAdenosylmethionineSAMecs.html, an excellent, objective resource for information on 'alternative medicine' that is provided by the University of Maryland Medical Center notes that:
Depression: The majority of studies have used between 800 and 1,600 mg of SAMe per day for depression. The daily dosage is typically split between morning and afternoon. --Substantiate 01:28, 17 February 2007 (UTC)
Are these dosages for the tosylate or butanedisulfonate salt? The latter is strongly reccomended in this areticle but is now almost impossible to find in the U.S. 66.245.159.152 20:40, 6 March 2007 (UTC)Andrew Hoerner
