Talk:Ryanodine receptor

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To write this, I will need to read PMID 15336975 JFW | T@lk 14:24, 9 May 2005 (UTC)

Here's a good source: http://pharmrev.aspetjournals.org/cgi/content/full/49/1/1 KBi 04:53, 15 November 2005 (UTC)

Wouldn't you add the full academic references and cite the key points in the article? JFW | T@lk 07:51, 15 November 2005 (UTC)

You're evil! It's 51 pages long! JFW | T@lk 20:12, 15 November 2005 (UTC)

[edit] From signal transduction

This should be incorporated here:

• The ryanodine receptor is named after the plant alkaloid ryanodine. It is similar to the InsP₃ receptor and stimulated to transport Ca²⁺ into the cytosol by recognizing Ca²⁺ on its cytosolic side, thus establishing a feedback mechanism; a small amount of Ca²⁺ in the cytosol near the receptor will cause it to release even more Ca²⁺. It is especially important in neurons and muscle cells. In heart and pancreas cells, another second messenger (cyclic ADP ribose) takes part in the receptor activation.

The localized and time-limited activity of Ca²⁺ in the cytosol is also called a Ca²⁺ wave. The building of the wave is done by

• the feedback mechanism of the ryanodine receptor and
• the activation of phospholipase C by Ca²⁺, which leads to the production of inositol triphosphate, which in turn activates the InsP₃ receptor.

JFW | T@lk 18:27, 9 May 2005 (UTC)