User talk:Roadnottaken

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[edit] Unspecified source for Image:Pharmacia deluxe.jpg

Thanks for uploading Image:Pharmacia deluxe.jpg. I notice the file's description page currently doesn't specify who created the content, so the copyright status is unclear. If you have not created this file yourself, then there needs to be a justification explaining why we have the right to use it on Wikipedia (see copyright tagging below). If you did not create the file yourself, then you need to specify where it was found, i.e., in most cases link to the website where it was taken from, and the terms of use for content from that page.

If the file also doesn't have a copyright tag, then one should be added. If you created/took the picture, audio, or video then the {{GFDL-self}} tag can be used to release it under the GFDL. If you believe the media meets the criteria at Wikipedia:Fair use, use a tag such as {{fairusein|article name}} or one of the other tags listed at Wikipedia:Image copyright tags#Fair_use. See Wikipedia:Image copyright tags for the full list of copyright tags that you can use.

If you have uploaded other files, consider checking that you have specified their source and tagged them, too. You can find a list of files you have uploaded by following this link. Unsourced and untagged images may be deleted one week after they have been uploaded, as described on criteria for speedy deletion. If you have any questions please ask them at the Media copyright questions page. Thank you. —Bkell (talk) 02:47, 6 August 2006 (UTC)

[edit] Welcome to the Wikipedia

Welcome, Roadnottaken!

Here are some useful tips to ease you into the Wikipedia experience:

Also, here are some odds and ends that I find useful from time to time:

Feel free to ask me anything the links and talk pages don't answer. You can most easily reach me by posting on my talk page.

You can sign your name on any page by typing 4 tildes, likes this: ~~~~.

Best of luck, and have fun! – ClockworkSoul 05:23, 29 November 2006 (UTC)

[edit] This month's winner is RNA interference!

RNA interference
This month's MCB Collaboration of the Month article is RNA interference.
Please help to improve this article to featured article status.
Last month's collaboration was proteasome

– ClockworkSoul 14:39, 2 December 2006 (UTC)

[edit] This month's MCB Collaboration of the Month article is Peripheral membrane protein!

Peripheral membrane protein
This month's MCB Collaboration of the Month article is Peripheral membrane protein.
Please help to improve this article to featured article status.
Last month's collaboration was RNA interference

– ClockworkSoul 18:59, 14 January 2007 (UTC)

[edit] Lipid Signaling

You added some good new material to Lipid signaling but also [1] blanked out a bunch of fair material. Was this by accident? By the way, your edits there are not minor. David.Throop 04:01, 20 February 2007 (UTC)

  • no it was not by accident, but i did not get a chance to finish the edit (is there a way to save a draft?). i'm taking most of the DAG/IP3 stuff out as it is thoroughly covered elsewhere and, personally, i think intercellular signaling molecules with dedicated GPCRs fit the definition of lipid signaling better. do you agree? Roadnottaken 15:09, 20 February 2007 (UTC)

[edit] Lipd signals and endocannibinoids

When I'm doing a major rework of a page, I create a sandbox. Then I can save every 100 keystrokes or so and not worry about cluttering up the history page of the article.

I restored the material you'd removed. If you think that something is better covered elsewhere, move it to the Talk: page. That gives the author a chance to weigh in. Even if it's better covered elsewhere, you should leave a couple of sentences as a summary, with a See detail at... linkage.

If you are removing more than a few keystrokes of somebody else's work, it is not a Minor Edit. Don't check the 'Minor Edit' box.

I'm still not clear just how the term 'lipid signalling' is used in the field, so I don't have an informed opinion about DAG/IP3.

Great to have an endocannibinoid resource around! Maybe you can explain something to me. In the eicosanoids, the biggest news of the last 20 years is that omega-3 EPA leads to families of eicosanoids that mitigate the activities (particularly the inflammatory activity) of the Arachidonic Acid derived eicosanoids. There's a tremendous amount of interest in the differential effect the AA-derived vs the EPA-derived eicosanoids. This interest extends out into the popular press.

In the endocannibinoids, EPA (and DHA?) form anandimide analogues. Do they modulate anandimide signaling in a way similar to the way the EPA-derivatives modulate the COX and 5-LO pathways? When I eat salmon, am I shaking up my CB1 / CB2 pathways? I've gone hunting for research articles on this and I'm find almost nothing. I'd think that this would be one of the most urgent questions in endocannibinoid research. Am I missing something? David.Throop 20:47, 20 February 2007 (UTC)

Oh, btw, thanks for the cool picture for lipid signalling. —The preceding unsigned comment was added by David.Throop (talk • contribs) 20:50, 20 February 2007 (UTC).
N-docosahexaenoyl ethanolamide is present in mouse-brain (at levels similar to anandamide) and i imagine any fatty acids from your diet would eventually work their way in to N-acylethanolamines at some concentration. that being said they are almost certainly less potent agonists of CB receptors than AEA. additionally, the biosynthetic pathways for AEA have not yet been thoroughly worked-out so the REGULATED production of these signaling lipids may turn out to be specific for AA. maybe not. in any event, you need to elevate the concentration of AEA quite a bit (by inhibiting FAAH) before you start seeing overt behavioral effects in mice (altho there are probably subtle phenotypes that we can't see in mice)... anyway my opinion is that all PUFA NAE derivates activate CB receptors at some level and that your diet probably does affect the distribution of PUFAs available for conversion to NAEs, but that the biosynthesis and degradation are probably tightly regulated such that you can't screw-up endocannabinoid signaling by changing your diet. i'll try to find some references supporting this view, but it's pretty unsubstantiated. to really do the experiment you'd have to feed animals high levels of 13C labled PUFAs which are very expensive. Roadnottaken 16:28, 21 February 2007 (UTC)


[edit] Visual Signaling

Sounds good – go ahead and create the article. I encourage you to build the article in your sandbox until you've got it up to 'first release' standard. Be bold.

But do make a thorough search first. I've started several articles only to realize later that I'd duplicated something already extant. Trick is to use the Search box on several cominations of likely keywords, and use the 'What links here' on some related articles. David.Throop 05:33, 23 February 2007 (UTC)

[edit] License tagging for Image:DAGv1.png

Thanks for uploading Image:DAGv1.png. Wikipedia gets thousands of images uploaded every day, and in order to verify that the images can be legally used on Wikipedia, the source and copyright status must be indicated. Images need to have an image tag applied to the image description page indicating the copyright status of the image. This uniform and easy-to-understand method of indicating the license status allows potential re-users of the images to know what they are allowed to do with the images.

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This is an automated notice by OrphanBot. If you need help on selecting a tag to use, or in adding the tag to the image description, feel free to post a message at Wikipedia:Media copyright questions. 18:05, 12 March 2007 (UTC)

[edit] License tagging for Image:Phospholipases.png

Thanks for uploading Image:Phospholipases.png. Wikipedia gets thousands of images uploaded every day, and in order to verify that the images can be legally used on Wikipedia, the source and copyright status must be indicated. Images need to have an image tag applied to the image description page indicating the copyright status of the image. This uniform and easy-to-understand method of indicating the license status allows potential re-users of the images to know what they are allowed to do with the images.

For more information on using images, see the following pages:

This is an automated notice by OrphanBot. If you need help on selecting a tag to use, or in adding the tag to the image description, feel free to post a message at Wikipedia:Media copyright questions. 19:11, 18 March 2007 (UTC)

[edit] Myriocin

Hello. Please don't forget to provide an edit summary. Thanks, and happy editing.

Please remember to mark your edits as minor when (and only when) they genuinely are minor edits (see Wikipedia:Minor edit). Marking a major change as a minor one (and vice versa) is considered poor etiquette. The rule of thumb is that only an edit that consists solely of spelling corrections, formatting and minor rearranging of text should be flagged as a 'minor edit'. Thanks! --Mel Etitis (Talk) 10:37, 20 March 2007 (UTC)

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