Talk:RNA virus
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[edit] HBV classified as an RNA virus?
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- Anyone have a source for the following claim (2nd sentence in the entry): "For example, Hepatitis B virus is classified as an RNA virus, even though its genome is double-stranded DNA, because the genome is transcribed into RNA during replication." I was under the impression that Hep B was classified as a reverse transcriptase DNA virus.[1] -- MarcoTolo 20:45, 15 April 2006 (UTC)
[edit] Factual accuracy disupted
Cheers, all, I'm RelentlessRouge. About standard RNA viruses and how they replicate, I'm not quite sure if that's right. What's written says the following (for negative-sense viruses):
RNA[-] ---> RNA[+](mRNA) ---> protein
How's the RNA replicate?
I might probably not know what the hell I'm talking about, but please enlighten me.
RelentlessRouge 11:27, 14 June 2006 (UTC)
- No worries, virus replication is a messy thing to understand. A negative-sense virus cannot have its genome read by host ribosomes until it has been converted into positive-sense RNA - the ribosomes just won't translate it. In order:
- The negative-sense strand of RNA is read by a host protein called RNA polymerase which makes a copy of it. This copy is now positive-sense - a bit like a mirror image.
- This positive-sense strand acts as messenger RNA (mRNA) for the virus, and is read by the host ribosome
- The ribosome constructs a protein based on what the mRNA tells it
- This protein goes on in a number of different, complicated ways to direct the synthesis of new virions - such as the creation of more negative-sense RNA strands and capsid proteins.
- Hopefully that helps. Thanks for pointing out that this might not be apparent at first glance, I'll update the article ☻ -- Serephine ♠ talk - 11:49, 14 June 2006 (UTC)
It would help if the definition of negative-sense is mentioned in this article, because the negative-sense article redirects to here. 87.243.196.213 08:29, 26 March 2007 (UTC)
[edit] Importance of RNA viruses
I suggest adding a line to the initial paragraph to emphasise the importance of these viruses.
Notable human RNA viruses include SARS, Influenza and HCV.
--TransControl 08:45, 28 July 2006 (UTC)
'As such, they possess ribonucleic acid (RNA) as their genetic material and do not replicate using a DNA intermediate' HIV is an RNA virus that uses a DNA intermeadiate
