Talk:Ribosome
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A Wikipedian removed Ribosome from the good article list. There are suggestions below for improving areas to satisfy the good article criteria. Once the objections are addressed, renominate the article as a good article. If you disagree with the objections, you can seek a review. |
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[edit] Ribosome removed from Wikipedia:Good articles
was formerly listed as a good article, but was removed from the listing because no refrencesv
It would be useful to describe theories how ribosomes were created in evolution.
Yes, it would. But it might also be premature to commit such a discussion to an encyclopedia, as work testing a leading hypothesis has really just started to be published. The Noller lab, in gradually stripping proteins from native ribosomes without totally destroying activity, helped advance the idea that the RNA, rather than the proteins, participate in crucial ribosome function. More recently, the Strobel lab has been trying to identify more exactly (large subunit RNA is still a huge molecule!) what part of the RNA is responsible for peptidyl transfer:
G. W. Muth, L. Ortoleva-Donnelly and S. A. Strobel, A single adenosine with a neutral pK[a] in the ribosomal peptidyl transferase center, Science 289, 947-950 (2000).
It might be useful to have a good idea of how it all works before going very far in trying to describe inferences as to how it came to work that way.
It is true that theories about the evolution of ribosomes, although extremely intriguing, are quite speculative at this time. However, it may be useful to mention the auto-catalytic capabilities of RNA molecules in general (the 'RNA world' hypothesis) as a possible starting point for the modern translational machinery. Wikipedia link: RNA_world
WK
[edit] Simplified Structural Image
It would be nice if there is a simplified image of the ribosome at the head of the document and then using the highly detailed structural images in the mid-section. I'm in the process of finding a diagram for this purpose as well as for the translation page. --G3pro 13:59, 15 Nov 2004 (UTC)
[edit] More Structure
I am writing my thesis about the ribosome, so I plan to expand the structural aspects of this page. Maybe some of the chemistry involved. Feel free to change anything I add. I like how the page starts, very general, so I will add to the bottom.
I just uploaded an original picture of the 50S subunit; the 30S and 70S subunits are forthcoming.
--vossman 14:04, September 1, 2005 (UTC)
Hi.
In my opinion, and from reading the ribozyme page, Ribosomes are not ribozymes (see comment in opening para of article). For the ribosome to work it requires the protein scaffold, it is not an RNA only enzyme. So at best ribosomes might be called ribo-proteozymes. Just a thought. Reveldrummond 00:44, 16 December 2005 (UTC)
- I guess you could argue that a ribozyme might have protein subunits. This recent article says, "the ribosome is a ribozyme".
-
- The ribosome is a ribozyme, because all the chemistry is performed by the RNA. Efforts are ongoing by the Green lab at Hopkins and Strobel and Steitz labs at Yale to produce a protein free peptidyl transferase RNA, but so far have been unsucessful. --vossman 03:25, 16 December 2005 (UTC)
FIGURE WRONG!! I am soory, I don't know the proper way of writing here, but I just wanna mention that The figure shows WRONG unit of lenght, the ribosome is not that big. it is aproximately 200 A not nm or 20 nm.
[edit] Amount of rRNAs in subunits
The mammalian 40S subunit contains 18S rRNA. The 60S subunit contains 5S, 5.8S and 28S RNA. This is not consistent with the text that says that each subunit contains one or two rRNAs. Prokaryotic ribosomes have indeed 1 or two rRNAs: the 30S subunit contains 16S rRNA, the 50S subunit contains 5S and 23S rRNA.--User:AAM | Talk 20:05, 11 May 2006 (UTC)
[edit] Size of Ribosome [nm]
"FIGURE WRONG!! I am soory, I don't know the proper way of writing here, but I just wanna mention that The figure shows WRONG unit of lenght, the ribosome is not that big. it is aproximately 200 A not nm or 20 nm."
I just wanted to emphasize that the size of ribosome in this article (the size of ribosome in nm is desplayed below the ribosome in figure 2) is about 10 times bigger than in reality, and there is some difference in size (nm) between the eukaryotic and prokaryotic ribosome. See http://en.wikibooks.org/wiki/Cell_biology:Size_of_cells or http://nai.arc.nasa.gov/news_stories/news_detail.cfm?ID=137 for quite exact size in nm.
- See link TimVickers 20:56, 31 March 2007 (UTC)
[edit] Where are they produced
Can we include information as to what organelle produces Ribosomes, or did I just miss it? AdamBiswanger1 23:44, 25 October 2006 (UTC)
- In prok's ribosomes form in the cytosol (no organelle), but in euk's ribosomes are produced in the nucleolus and exported. This page is very prok focused, so I don't think it fits in. --vossman 01:12, 26 October 2006 (UTC)
[edit] Definition of Ribosomes/Organelles
Organelles are generally defined as having lipid or phospholipid membranes. Ribosomes have no such membranes (they consist only of rRNA and proteins), so they shouldn't be technically classified as organelles, yet the article classifies them as such anyway. Have I missed something here? 68.221.210.250 01:20, 4 January 2007 (UTC)JackMerridew
- As discussed at Organelle, different people use the term "organelle" in different ways. Some people count ribosomes as a type of organelle. --JWSchmidt 01:39, 4 January 2007 (UTC)
- I agree with JWSchmidt, organelle isnt a well defined term and is used in many ways. - Zephyris Talk 10:06, 4 January 2007 (UTC)
- Okay, I can accept that. It would be nice if there were more definitive criteria for defining an organelle, though. I admit to some confusion. —The preceding unsigned comment was added by 68.221.216.6 (talk) 22:18, 5 January 2007 (UTC).
[edit] Please revise
In the section structure it is said that prokrayotes have 70S ribosomes (30S sub nit and 50S sub unit) Doesn't that make 80S :S
- Not needed. Logically you would think so, but S refers to Svedburg units which are bases on density/sedimentation so the units are NOT additive they are determined experimentally. Hichris 15:44, 14 February 2007 (UTC)
