Talk:Reversible inhibition of sperm under guidance
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How does this work exactly? It doesn't sound like real science at first glance... — Omegatron 14:39, September 7, 2005 (UTC)
Well, I'm not a regular Wiki user... so I'm not familiar with the technical side of things here... but isn't everything explained if you actually go and read the articles? The Ottawa U professor in Canada lives in my neighbourhood, and I contacted him over email. He went to India and performed the procedure there, but can't get funding to start trials in Canada. The articles talk about him. Sure it sounds too good to be true but I can only be so skeptical as I'm not a doctor.... but I want to know why we are not hearing MORE about it. etc etc. I just thought the dispute banner at the top of the page was weird.. so I had so say something... oh... and I want to add... I'd like to see a DOCTOR dispute it, rather than you simply saying "it sounds bogus".... haven't you ever watched shows like Ripley's Believe it or Not?? and I mean it in the nicest way. Some things on Ripleys amaze me... and seem to stump the experts too, but they are true. vaalea 29Nov05
Yes, me too found it weird, certainly for just that, although the article does sound a bit like an advertisment.
If you have issue with the way the article is phrased that is a valid complaint, however the article does come with supplemental links that explain in more detail how it works and why, so the use of the dispute banner here just seems like random mudslinging. There are articles about this in scientific journals and a simple google search will bring up even more references. http://www.media.uottawa.ca/mediaroom/news_details-e.php?nid=254 http://www.newscientist.com/article.ns?id=mg18124294.600 http://www.reproduction-online.org/cgi/content/abstract/122/3/431
- It doesn't matter if the info is in the external links. It needs to be in the article.
- i don't watch tv. i don't even have one. :-) and i certainly wouldn't expect to get any reliable information from it. even supposedly reliable science/history channels skew or exaggerate facts for ratings. i'm not saying it looks bogus from a medical standpoint. i'm saying the article's description looks bogus from a biology/physics standpoint.
- it reads just like an advertisement. — Omegatron 00:44, 2 December 2005 (UTC)
Better descriptions:
- and is composed of a styrene malic anhydride (SMA) complexed with the solvent DMSO.
- RISUG has two contraceptive effects: partial blockage of the vas and molecular-level electrical charges. The positive and negative charge mosaic on RISUG's surface causes the membranes of passing sperm to rupture, rendering them incapable of fertilizing an egg. [1]
- The animal studies and phase I and phase II clinical trials with the injectable contraceptive RISUG, a specific copolymer of styrene with maleic anhydride dissolved in 60 mg solvent of dimethyl sulphoxide, have indicated that the new technique is safe and efficacious. A phase III clinical trial with this preparation has been initiated to evaluate the safety and efficacy of the drug in a large number of subjects. All the subjects will be followed up for six months following treatment to study the immediate and long term adverse effects, semenology and pregnancy protection. A total of 16 subjects have been enrolled in the study. [2]
- A polymer, stryrene maleic anhydride, is injected into the vas deferens, forming a coating around the inside of this tubule; SMA lowers the pH of the environment just enough to kill sperm passing through. SMA can be flushed out with an injection of dimethyl sulfoxide or allowed to dissolve at a time which can be set for anywhere between two months and five years. SMA has been tested for ten years in rats and monkeys and is now in human trials in India; it has been said to show excellent effectiveness and reversibility, with no toxicity or teratogenicity. [3]
- Work by the present inventors on injecting styrene maleic anhydride in a solvent vehicle of dimethyl sulphoxide has been reported in Contraception 1993 : 48 October. Such a publication discloses in vitro pH-lowering effect but does not discuss the effect on the fertilizing ability of sperms.
- a polymer which is an active compound and affects fertilizing ability of sperms, and the acrosin and hyaluronidase enzymes.
- The manner in which the contraceptive of the present invention works has still not been fully ascertained, except that in distinction to what has been disclosed in the aforesaid publication, just a lowering of the pH does not provide the necessary results and that other properties are required of the contraceptive.
- After irradiation, the copolymer is precipitated by adding petroleum ether (60/80 grade) and then washed for removal of traces of monomers, homopolymers and maleic anhydride. The copolymer is dried and dissolved in 1,2 dichloro ethane for removal of styrene monomer. The polymer solution was filtered and filterate precipitated. The precipitated copolymer is washed, dried and stored. [4]
- Biophysical basis of the mechanism of action of a new injectable male contraceptive RISUG
Dr Koel Chaudhury and Prof. Sujoy K. Guha
School of Medical Science &\1 Technology, Indian Institute of Technology, Kharagpur. [5]
