Talk:Regulatory T cell
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I think that the definitions (their basic origins and proposed roles, not their molecular biology, that can be left for other sections) between TH3 (and other subsets) and Treg suppressor T cells must be clearly explained, as the former subsets are hardly or not mentioned at all. It should also be pointed out that the term "regulatory" is applied to suppressor T cells, but in reality effector T cells also regulate helper T cell responses. The terms are particularly confusing considering the TH1/TH2 model. Volantares 09:34, 19 November 2005 (UTC)
Th3 and Tr1 are just names for cell subsets that people generate in vitro. It's just a name. They may, or may not, have any relevance in vivo. I think the evidence from the IBD models is that IL-10, TGF-beta and CTLA-4 are all required for full Treg function, to greater or lesser extent. Treg are a heterogenous population which can, under different conditions, produce a wide range of cytokines. The Th1/Th2/Th17/Treg paradigm is fairly sound - each with their own transcription factor, method of differentation and key cytokines - but the Tr1 and Th3 subtypes are a little shakier. Kantokano 18:21, 15 December 2006 (UTC)
While your point about in vivo relevance is not unimportant, the current literature simply isn't capable of synthesizing those in vitro models of alternative "suppressor" populations -- thus far, the population that has the most evidence for in vivo, physiologic, and clinical application is the FoxP3+ Treg. This does not necessarily discount, or exclude the existence of Th3 or Tr1 cells, but those models simply aren't supported as well by in vivo work. I might also remind of the transwell experiments from the Shevach lab, which still support cell-contact as a necessary mechanism for classically defined Treg suppression in vitro. Jbarin 04:37, 14 January 2007 (UTC)
I don't know if that's true. i cant be sure. this website is shit, i can type anything into it- may it be true or false. How the hell are you gonna know?
(reply to message above by 207.6.160.178):
RESPONSE MOVED TO IP'S TALK PAGE: User_talk:207.6.160.178
Chrisch 06:28, 11 December 2006 (UTC)
