Rathke's pouch

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Rathke's pouch

Sketches in profile of two stages in the development of the human digestive tube.
Gray's	subject #275 1277
Carnegie stage	10
Gives rise to	anterior pituitary
Dorlands/Elsevier	p_31/12662673

In embryogenesis, Rathke's pouch is a depression in the roof of the developing mouth in front of the buccopharyngeal membrane. The pouch eventually loses its connection with the pharynx giving rise to the anterior pituitary. The anterior wall of Rathke's pouch proliferates, filling most of the pouch to form pars distalis and pars tuberalis. The posterior wall forms pars intermedia.

In some organisms (humans being a notable exception), the proliferating anterior wall does not fully occupy Rathke's pouch, leaving a remnant (Rathke's cleft) between the pars distalis and pars intermedia. Rathke's pouch may also persist as cysts (Rathke's cysts) within the pars intermedia.