RANKL

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tumor necrosis factor (ligand) superfamily, member 11
Identifiers
Symbol	TNFSF11
HUGO	11926
Entrez	8600
OMIM	602642
RefSeq	NM_003701
UniProt	O14788
Other data
Locus	Chr. 13 q14

RANKL (Receptor Activator for Nuclear Factor κ B Ligand) is a molecule important to bone metabolism. This natural and necessary messenger molecule activates osteoclasts, cells involved in bone resorption. Overproduction of RANKL is implicated in a variety of degenerative bone diseases, like rheumatoid arthritis.

Contents 1 See also 2 Reference 3 External links 4 External links

[edit] See also

• RANK
• osteoprotegerin

[edit] Reference

• Whyte M (2006). "The long and the short of bone therapy". N Engl J Med 354 (8): 860-3. PMID 16495400.  link

[edit] External links

• http://www.networksandpathways.org/pathway?name=RANKL&description=RANKL

[edit] External links

• MeSH RANKL+Protein