R&B number-one hits of 1988 (USA)
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These are the Billboard magazine R&B singles chart number one hits of 1988:
See also: 1988 in music, List of number-one R&B hits (United States)
| Issue Date | Song | Artist |
| January 2 | The Way You Make Me Feel | Michael Jackson |
| January 9 | The Way You Make Me Feel | Michael Jackson |
| January 16 | The Way You Make Me Feel | Michael Jackson |
| January 23 | Love Overboard | Gladys Knight & the Pips |
| January 30 | I Want Her | Keith Sweat |
| February 6 | I Want Her | Keith Sweat |
| February 13 | I Want Her | Keith Sweat |
| February 20 | Girlfriend | Pebbles |
| February 27 | Girlfriend | Pebbles |
| March 5 | You Will Know | Stevie Wonder |
| March 12 | Fishnet | Morris Day |
| March 19 | Fishnet | Morris Day |
| March 26 | Man In the Mirror | Michael Jackson |
| April 2 | Wishing Well | Terence Trent D'Arby |
| April 9 | Ooo La La La | Teena Marie |
| April 16 | Get Out Of My Dreams, Get Into My Car | Billy Ocean |
| April 23 | Da Butt | E.U. |
| April 30 | Nite and Day | Al B. Sure! |
| May 7 | Nite and Day | Al B. Sure! |
| May 14 | Nite and Day | Al B. Sure! |
| May 21 | Mercedes Boy | Pebbles |
| May 28 | Just Got Paid | Johnny Kemp |
| June 4 | Just Got Paid | Johnny Kemp |
| June 11 | Little Walter | Tony! Toni! Tone! |
| June 18 | One More Try | George Michael |
| June 25 | Joy | Teddy Pendergrass |
| July 2 | Joy | Teddy Pendergrass |
| July 9 | Paradise | Sade |
| July 16 | Roses Are Red | The Mac Band featuring the McCampbell Brothers |
| July 23 | Don't Be Cruel | Bobby Brown |
| July 30 | Don't Be Cruel | Bobby Brown |
| August 6 | Off On Your Own (Girl) | Al B. Sure! |
| August 13 | Off On Your Own (Girl) | Al B. Sure! |
| August 20 | Loosey's Rap | Rick James featuring Roxanne Shanté |
| August 27 | Nice N Slow | Freddie Jackson |
| September 3 | Nice N Slow | Freddie Jackson |
| September 10 | Nice N Slow | Freddie Jackson |
| September 17 | Another Part Of Me | Michael Jackson |
| September 24 | She's On the Left | Jeffrey Osbourne |
| October 1 | Addicted To You | LeVert |
| October 8 | Addicted To You | LeVert |
| October 15 | My Prerogative | Bobby Brown |
| October 22 | My Prerogative | Bobby Brown |
| October 29 | The Way You Love Me | Karyn White |
| November 5 | Any Love | Luther Vandross |
| November 12 | Giving You the Best That I Got | Anita Baker |
| November 19 | Giving You the Best That I Got | Anita Baker |
| November 26 | Thanks For My Child | Cheryl "Pepsii" Riley |
| December 3 | Hey Lover | Freddie Jackson |
| December 10 | Dial My Heart | The Boys |
| December 17 | Everything I Miss At Home | Cherrelle |
| December 24 | Tumblin' Down | Ziggy Marley & the Melody Makers |
| December 31 | Tumblin' Down | Ziggy Marley & the Melody Makers |
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