Talk:Prostaglandin

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Contents 1 15PGJ2 2 Paturition link 3 Enzymes 4 Enzymes 5 Plants prostaglandins 6 Prostaglandin antagonist

[edit] 15PGJ2

I removed "15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2)is a PGD2 derivative that acts on PPAR intracellular receptors" because this proposition has since been proven false. [1] Mazzo 01:09, 11 August 2006 (UTC)

[edit] Paturition link

I don't understand adding a Parturition link right after the childbirth one. Not only do they mean the same thing, but Parturition just gets redirected to childbirth. But I'm leaving the link in for the moment. David.Throop 15:48, 15 February 2006 (UTC)

Childbirth commences with labour. Parturition commences with the actual moving of the child through the birth canal. In other words: if labour is not progressing to parturition, prostaglandins may be of help. JFW | T@lk 00:23, 16 February 2006 (UTC)

[edit] Enzymes

Hi,

Just to point out that the conversion of prostacyclin to both prostaglandin and thromboxane first involves the enzyme 'cyclo-oygenase' before postacyclin synthatase and thromboxane synthatase respectively.

[edit] Enzymes

The relavance of this is in the treatment fo hypertension. Drugs called NSAIDs inhibit cyclo-oxygenase. This leads to the reduced production of thromboxane (a vasoconstrictor and coagulant) but not prostacyclin as the former is produced in platelets which do not have the capacity to synthesise new cyclo-oxygenase whereas new prostacyclin can be produced by the nuclei of the endothelial cells it is produced in.

[edit] Plants prostaglandins

Prostaglandins and prostaglandin-like substances have also been found in plants. This fact maybe should be mentioned in the article. Tavilis 19:31, 8 September 2006 (UTC)

[edit] Prostaglandin antagonist

User:Arcadian has split the section on inhibition off as another section. That's OK, but I think it's mis-titled.

An antagonist (in these contexts) is a substance that binds a receptor. (Who says so? Well, follow the links from Prostaglandin antagonist to Hormone antagonist to Receptor antagonist.) NSAIDs compete for COX; aspirin actually irreversably reacts with COX. COX and phospholipases aren't receptors. They're enzymes.

The body itself does produce prostaglandin antagonists. E.g., the prostaglandins made from EPA and DGLA (sometimes) reduce inflammation by acting as antagonists for the prostaglandin receptors. That is, they block the action of the AA-derived PGs.

So I think the new article should be titled Prostaglandin inhibition.

Also, when splitting off a section into it's own article, one should leave a couple of sentences that summarize the section. David.Throop 19:19, 28 February 2007 (UTC)

I used the term "antagonist" to align with the terminology used by the United States National Library of Medicine, which defines "Prostaglandin Antagonists" as "Compounds that inhibit the action of prostaglandins", without limiting it to action occuring at the receptor. However, on that page, MeSH also lists "Prostaglandin Inhibitors" as an alternate entry term. Feel free to change the pages as needed, though I do think that "inhibitor" would be better than "inhibition". --Arcadian 21:27, 28 February 2007 (UTC)

Hmmm. Well Dorland's allows for enzyme antagonists. But in that sense, inhibiting COX or the phospholipases doesn't inhibit PG's action. They inhibit PG's production. So NSAIDs could rightly be called 'COX antagonists'.

I may be demanding more precision out of the term than is typically used. (I.e, I may be being pedantic.) But a quick search at [scholar.google.com Google Scholar] on "prostaglandin antagonists" seemed to be returning refs to compounds that (I think) are acting at the PG receptors, not NSAIDs.David.Throop 21:54, 28 February 2007 (UTC)