Protease inhibitor (biology)
From Wikipedia, the free encyclopedia
For the drugs used in AIDS, please refer to protease inhibitor (pharmacology).
In biology and biochemistry, protease inhibitors are molecules that inhibit the function of peptidases (old name: protease, hence the term protease inhibitor). Many naturally-occurring protease inhibitors are proteins.
In medicine, protease inhibitor is often used interchangeably with alpha 1-antitrypsin (A1AT, which is abbreviated Pi for this reason).[1] A1AT is indeed the protease inhibitor most often involved in disease, namely in alpha 1-antitrypsin deficiency.
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[edit] Classification
Protease inhibitors may be classified either by the type of protase the inhibit, or by their mechanism of action.
[edit] By protease
Classes of proteases are:
- Cysteine protease inhibitors
- Serine protease inhibitors (serpins)
- Trypsin inhibitors
- Threonine protease inhibitors
- Aspartic protease inhibitors
- Metalloprotease inhibitors
[edit] By mechanism
Classes of inhibitor mechanisms of action are:
- Suicide inhibitor
- Transition state inhibitor
- Protein protease inhibitor (See serpins)
- Chelating agents