Propionyl-CoA
From Wikipedia, the free encyclopedia
| Propionyl-CoA | |
|---|---|
 |
|
| Identifiers | |
| CAS number | [] |
| PubChem | |
| MeSH | |
| Properties | |
| Molecular formula | C24H40N7O17P3S |
| Molar mass | 823.599 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
|
Propionyl-CoA is a coenzyme A derivative of propionic acid.
It is formed as a product of beta-oxidation of odd-chain fatty acids, which occur in meat of ruminant animals. It is also a product of metabolism of isoleucine and valine. In mammals propionyl-CoA is converted to (S)-methylmalonyl-CoA by propionyl-CoA carboxylase, a biotin-dependent enzyme also requiring bicarbonate and ATP. This product is converted to (R)-methylmalonyl-CoA by methylmalonyl-CoA racemase. (R)-Methylmalonyl-CoA is converted to succinyl-CoA by methylmalonyl-CoA mutase, an enzyme requiring cobalamin to catalyze the carbon-carbon bond migration. A defect in methylmalonyl-CoA mutase enzyme results in methylmalonic aciduria, a dangerous disorder that causes a lowering of blood pH.
In plants and insects propionyl-CoA is metabolized to acetate in a very different way, similar to beta oxidation. Not all details of this pathway have been worked out, but it appears to involve formation of acrylyl-CoA, then 3-hydroxypropionyl-CoA. This is metabolized with loss of carbon 1 of 3-hydroxypropionyl-CoA as carbon dioxide, while carbon 3 becomes carbon 1 of acetate.
[edit] Reference
Halarnkar, P.P., Blomquist, G.J. (1989) Comparative aspects of propionate metabolism. Comp. Biochem. Physiol. 92B, 227-231.
 |
This article is uncategorized.
Please help improve this article by adding it to one or more categories, so it may be associated with related articles (how?). Please remove this tag after categorizing, but not before. |
