Propanidid
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Propanidid
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| Systematic (IUPAC) name | |
| propyl 2-[4-(diethylcarbamoylmethoxy)-3-methoxy- phenyl]acetate |
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| Identifiers | |
| CAS number | |
| ATC code | N01 |
| PubChem | |
| Chemical data | |
| Formula | C18H27NO5 |
| Mol. mass | 337.411 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Propanidid is an ultra short-acting phenylacetate general anesthetic. It was originally introduced by Bayer but anaphylactic reactions caused it to be withdrawn shortly afterwards.
Cremophor EL was the solubilizing agent (excipient / additive) of Propanidid. It should be emphasized that there is no evidence of any toxic action from Cremophor in man. The toxic effects or reactions to Propanidid and Althesin are due to the drugs themselves [1].
[edit] References
- ^ A new Steroid Anaesthetic - Althesin (pdf). PubMed. Retrieved on January 7, 2007. See page 1/49
[edit] External links
- Klockgether-Radke A, Kersten J, Schröder T, Stafforst D, Kettler D, Hellige G (1995). "Anesthesia with propanidid in a liposomal preparation. An experimental study in swine". Anaesthesist 44 (8): 573-80. PMID 7573906.
- Habazettl H, Vollmar B, Röhrich F, Conzen P, Doenicke A, Baethmann A (1992). "Anesthesiologic efficacy of propanidid as a liposome dispersion. An experimental study with rats". Anaesthesist 41 (8): 448-56. PMID 1524155.
- Zawisza P, Przyborowski L (1992). "[Propanidid and etomidate identification from the blood by thin-layer chromatography]". Acta Pol Pharm 49 (5-6): 15-7. PMID 16092193.
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| Barbiturates | Hexobarbital, Methohexital, Narcobarbital, Thiopental |
| Ethers | Diethyl ether,Desflurane, Enflurane, Isoflurane, Methoxyflurane, Methoxypropane, Sevoflurane, Vinyl ether |
| Haloalkanes | Chloroform, Halothane, Trichloroethylene |
| Opioids | Alfentanil, Anileridine, Fentanyl, Phenoperidine, Remifentanil, Sufentanil |
| Others | Alfaxalone, Droperidol, Esketamine, Etomidate, Hydroxybutyric acid, Ketamine, Minaxolone, Nitrous oxide, Propanidid, Propofol, Xenon |
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