Progestin-induced virilisation

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Progestin-induced virilisation is a cause of intersex in individuals with an XX karyotype, where the developing fetus is exposed to androgens in the womb.

In this case, the male hormones are caused by use of progestin, a drug that was used in the 1950s and 1960s in order to prevent miscarriage. These individuals have internal and external female anatomy. They develop however some male secondary sex characteristics, and they frequently have unusually large clitorises.