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Species in the genus Priscileo were the most primitive of Thylacoleonidae and were found in South Australia and Queensland. It was about the size of a possum and was less powerful than the other marsupial lions. The 2 species have crushing molar teeth (as in omnivorous kangaroos) as well as carnassial blades (large, flesh cutting teeth derived from the first lower molar and last upper molar). P. roskellyae may have been an arboreal species.
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