Pre-replication complex
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A pre-replication complex is a protein complex that forms at the origin of replication during the initiation step of DNA replication.
The following factors make up the complex in prokaryotes:
- A helicase such as dnaA, which unwinds the DNA ahead of the replication fork.
- A primase such as dnaG, which generates an RNA primer to be used in DNA replication.
- A DNA holoenzyme, which is actually a complex of enzymes that performs the actual replication.
In eukaryotes, a six-subunit Origin Recognition Complex (ORC) first binds to origin. Subsequently recruited is Cdc6, Cdt1, and finally the helicase MCM (Minichromosome Maintenance) complex.
[edit] External links
Origin of replication/Ori/Replicon - DNA clamp - Okazaki fragment - Replication fork (Lagging and leading strands) - Single-strand binding protein - Primer - Processivity - Klenow fragment
Pre-replication complex: Helicase (dnaA, dnaB, T7) - Primase (dnaG) - DNA polymerase III holoenzyme (dnaQ)
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