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- O'Brian, Murchadh of the Isle (1115-1137), king
- O'Brian, Patrick (1914-2000), British author
- O'Brien, Aaron (born 1981), Australian cricketer
- O'Brien, Edna (born 1930), Irish novelist
- O'Brien, Flann (born 1911), Irish writer
- O'Brien, Conan (born 1963), American comedian & journalist
- O'Brien, Loughlin, New Zealand politician
- O'Brien, Richard (born 1942), British writer & actor
- O'Brien, Robert C. (1918-1973), author
- O'Brien, Tim (born 1946), American author
- O'Brien, Tim, American musician
- O'Callaghan, Pat (1905-1991), Irish hammer thrower
- O'Carolan, Turlough (fl. 17th century), Irish harpist & composer
- O'Casey, Sean (1880-1964), playwright
- O'Connell, Arthur (1908-1981), actor
- O'Connell, Daniel (1776-1847), Irish activist
- O'Connell, Kevin (fl. late 20th century), American journalist
- O'Connell, Kevin, Irish cultural figure
- O'Connell, Paul (born 1979), Irish rugby player
- O'Connor, Bryan (born 1946), astronaut
- O'Connor, Carroll (1925-2001), American actor
- O'Connor, Des (born 1932), British comedian
- O'Connor, Donald (1925-2003), performer
- O'Connor, Edwin (1918-1968), American writer
- O'Connor, Feargus (1794-1855), Irish activist
- O'Connor, Flannery (1925-1964), American author
- O'Connor, Frank (1897-1979), actor
- O'Connor, Frank (1903-1966), writer
- O'Connor, Hazel (born 1955), British singer
- O'Connor, Mark (born 1961), American musician
- O'Connor, Richard (1889-1981), British soldier
- O'Connor, Sandra Day (born 1930), American jurist
- O'Connor, Sinéad (born 1966), Irish singer & activist
- O'Connor, Ulick (born 1929), Irish cultural figure
- O'Conor, Herbert R. (1896-1960), American politician
- O'Crohan, Thomas
[edit] O D - O R
- O'Day, Alan (born 1940), American musician
- Ó hAilpín, Aisake (born 1985), Irish hurling player & footballer -- Australian rules
- Ó hAilpín, Seán Óg (born 1977), Irish hurling player & footballer -- Gaelic rules
- Ó hAilpín, Setanta (born 1983), Irish hurling player & footballer -- Australian rules
- O'Hair, Madalyn Murray (1919-1995), American activist
- O'Hanlon, George (1912-1989), actor & director
- O'Hanrahan, Michael (1877-1916), British Irish activist
- O'Hara, Catherine (born 1954), Canadian-born American actor
- O'Hara, Frank (1926-1966), American poet
- O'Hara, Geoffrey (1882-1967), Canadian songwriter
- O'Hara, George (1899-1966), American actor
- O'Hara, Jean (fl. 1940s), American prostitute
- O'Hara, Mary, harpist & singer
- O'Hara, Maureen (born 1920),Irish actor
- O'Hara, Paige (born 1956), American actor
- O'Hare, Edward (1914-1943), American sailor
- O'Herlihy, Dan (1919-2005), Irish actor
- O'Higgins, Bernardo (1778-1842), Chilean activist & politician
- O'Loughlin, Alex (born 1977), Australian actor
- O'Malley, Stephen (fl. 2000s), American musician
- O'Neal, Alexander (born 1953), American singer
- O'Neill, Alexandre (1924–1986), Portuguese poet
- O'Reilly, Alejandro (1722–1794), Spanish colonial administrator
