Porphobilinogen synthase

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Porphobilinogen synthase
Identifiers
Symbol ALAD
HUGO 395
Entrez 210
OMIM 125270
RefSeq NM_001003945
UniProt P13716
Other data
EC number 4.2.1.24
Locus Chr. 9 q32

Porphobilinogen synthase (or ALA dehydratase, or Aminolevulinate dehydratase) synthesizes porphobilinogen through the asymmetric condensation of two molecules of aminolevulinic acid. All natural tetrapyrroles, including hemes, chlorophylls and vitamin B12, share porphobilinogen as a common precursor.

It is involved in the second step of the metabolism of porphyrin.

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Porphyrin biosynthesis enzymes

Aminolevulinic acid synthase - Porphobilinogen synthase - Porphobilinogen deaminase - Uroporphyrinogen III synthase - Uroporphyrinogen III decarboxylase - Coproporphyrinogen III oxidase - Protoporphyrinogen oxidase - Ferrochelatase

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