Porphobilinogen deaminase

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hydroxymethylbilane synthase
Identifiers
Symbol HMBS PBGD, UPS
HUGO 4982
Entrez 3145
OMIM 609806
RefSeq NM_000190
UniProt P08397
Other data
EC number 2.5.1.61
Locus Chr. 11 q23.2-qter

Porphobilinogen deaminase (or hydroxymethylbilane synthase) is an enzyme involved in the third step of the metabolism of porphyrin, converting porphobilinogen into hydroxymethyl bilane.

Older sources categorize it under EC 4.3.1.8.

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Porphyrin biosynthesis enzymes

Aminolevulinic acid synthase - Porphobilinogen synthase - Porphobilinogen deaminase - Uroporphyrinogen III synthase - Uroporphyrinogen III decarboxylase - Coproporphyrinogen III oxidase - Protoporphyrinogen oxidase - Ferrochelatase

v • d • e
Alkyl and aryl transferases (EC 2.5)

Dihydropteroate synthetase - Porphobilinogen deaminase - Spermidine synthase - Thiaminase I

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