Platelet-derived growth factor receptor

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platelet-derived growth factor receptor, alpha polypeptide
Identifiers
Symbol PDGFRA
HUGO 8803
Entrez 5156
OMIM 173490
RefSeq NM_006206
UniProt P16234
Other data
Locus Chr. 4 q12
platelet-derived growth factor receptor, beta polypeptide
Identifiers
Symbol PDGFRB PDGFR
HUGO 8804
Entrez 5159
OMIM 173410
RefSeq NM_002609
UniProt P09619
Other data
Locus Chr. 5 q31-q32

There are two known platelet derived growth fator receptors termed PDGFR-alpha and PDGFR-beta.

  • PDGFR-a binds all PDGF isoforms (PDGF-AA,PDGF-AB and PDGF-BB).
  • PDGFR-b binds PDGF-BB with high affinity, PDGF-AB with lower affinity, but does not to bind PDGF-AA with any appreciable affinity.

Both receptors are coupled to tyrosine kinase.

It has been shown that PDGF-b receptors are not present in healthy tissue in vivo but are upregulated in response to inflammation. It is unknown if PDGF-a behaves in the same way.

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Transmembrane receptor, tyrosine kinase: receptor tyrosine kinases

Angiopoietin Receptors: Tie-1 & Tie-2 - Eph - Epidermal growth factor (HER2/neu, Her 3, Her 4) - Fibroblast growth factor (FGFR2) - Flk-1 Flt-1 Insulin - IGF-1 - MuSK - Platelet-derived growth factor - TRK (TrkA, TrkB, TrkC), VEGF Receptors: Flt-1 & KDR/Flk-1,

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