Pick's disease

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Pick's Disease
Classification & external resources
ICD-10 G31.0
ICD-9 331.11

Pick's disease has a number of meanings:

1) Pick's disease is the old name for the disorder frontotemporal lobar degeneration (FTLD) and in particular the behavioural variant frontotemporal dementia (FTD). Certainly a number of patient support groups continue to use the name "Pick's disease" in their titles. This confusion has led many neurologists to suggest other names for FTLD. The most prominent is perhaps Kertesz' suggestion of the term "Pick Complex" to encompass not only the clinical subtypes of FTLD, but also the overlapping syndromes of corticobasal degeneration and progressive supranuclear palsy.

2) Neurologists use the term "Pick's disease" to mean specifically one of the pathological subtypes of FTLD. The pathological hallmark of Pick's disease are Pick bodies. These are spherical cytoplasmic inclusions found within neurons in affected portions of the brain.[1] They cause neurons to swell, taking on a "ballooned" appearance. Pick bodies contain the protein Tau, and hence the disease is also referred to as a tauopathy (along with progressive supranuclear palsy, corticobasal degeneration, and others). Currently, it is not possible to clinically distinguish between Pick's disease and other causes of FTLD prior to autopsy.

Contents

[edit] History

The Czechoslovakian neurologist and psychiatrist Arnold Pick first described the clinical syndrome of FTLD and characteristic neuronal inclusions, or Pick bodies, associated with Pick's disease in 1892.[1] At first, Pick's Disease was thought to be a form of Alzheimer's Disease, and it was not independently studied. [2]

[edit] See also

For more information on Pick's Disease, see the article on frontotemporal lobar degeneration (FTLD) and its clinical subtypes:

[edit] References

  1. ^ Pick A. (1892) Über die Beziehungen der senilen Hirnatrophie zur Aphasie. Prager medicinische Wochenschrift 17:165-167.
  2. ^ Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, Freedman M, Kertesz A, Robert PH, Albert M, Boone K, Miller BL, Cummings J, Benson DF. (1998) Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 51(6):1546-54. Link

[edit] External links

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