Phosphopantetheine

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Phosphopantetheine
Identifiers
CAS number [2226-71-3]
PubChem 987
MeSH phosphopantetheine
Properties
Molecular formula C11H23N2O7PS
Molar mass 358.349 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

4'-Phosphopantetheine is an essential prosthetic group of acyl carrier protein (ACP) and peptidyl carrier proteins (PCP) and aryl carrier proteins (ArCP) derived from Coenzyme A.

[edit] Functions

Phosphopantetheine fulfils two demands.

  • Firstly, the intermediates remain covalently linked to the synthases (or synthetases) in an energy-rich thiol ester linkage.
  • Secondly, the flexibility and length of phosphopantetheine chain (approximately 2 nm) allows the covalently tethered intermediates to have access to spatially distinct enzyme active sites.

[edit] See also

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This article is of interest to the Metabolic Pathways WikiProject.
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