Paul Zamecnik

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Paul C. Zamecnik (1912- )is an American scientist who, with Mahlon Hoagland, co-discovered tRNA, and was later credited as the inventor of antisense therapeutics. Zamecnik earned over a dozen US patents for his therapeutic techniques.

Paul Zamecnik was born in Cleveland, Ohio. He attend Dartmouth College, majored in Chemistry and Zoology, and received his AB degree in 1933. He then attended Harvard Medical School and received his MD degree in 1936. After internship and residency, he returned to the Boston area. He began teaching at Harvard Medical School in 1942, and from 1956 to 1979 he was both a Professor there and a Physician at Massachusetts General Hospital.

He has won many distinguished awards for his work, including the National Medal of Science (1991) and the first-ever Lasker Award for Special Achievement (1996). He is a member of the US National Academy of Sciences.


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