Pasha (protein)

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Pasha, also known as DGCR8, is a protein localized to the cell nucleus that is required for microRNA processing. It binds to Drosha, an RNase III enzyme, to form the Microprocessor complex that cleaves a primary transcript known as pri-miRNA to a characteristic stem-loop structure known as a pre-miRNA, which is then further processed to siRNA fragments by the enzyme Dicer. Pasha contains an RNA-binding domain and is thought to bind pri-miRNA to stabilize it for processing by Drosha.

[edit] References

  • Yeom KH, Lee Y, Han J, Suh MR, Kim VN. (2006). Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing. Nucleic Acids Res 34(16):4622-9.
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