Talk:Paroxysmal nocturnal hemoglobinuria
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I've been diagnosed with PNH but I think that many of my symptoms point to a G6PD deficiency.
- Well, your haematologist should surely be able to disentangle your haemolysis. Flow cytometry results? JFW | T@lk 14:39, 20 September 2005 (UTC)
Contents |
[edit] Eculizumab
PMID 15985537 - eculizumab works. Worth putting this in? JFW | T@lk 14:39, 20 September 2005 (UTC)
[edit] Work
I'll be expanding this article with the consensus statement in Blood 1 Dec 2005. JFW | T@lk 21:45, 20 December 2005 (UTC)
[edit] Acclaim
Excellent article, and is easy to read...great for a second year medical student.
- I hope it is understandable also to those without a medical background. Feel free to show it to your tutors & encourage them to improve it. It's a wiki! JFW | T@lk 22:07, 8 March 2006 (UTC)
[edit] Chromosome 12 mutations underlying clonality
It has been unclear why PNH is a clonal bone marrow disorder. PMID 16940417 gives data from 2 PNH patients with chromosome 12 abnormalities leading to ectopic expression of HMGA2 in bone marrow. I don't think we should cite this until the findings have been replicated in larger cohorts of PNH patients. JFW | T@lk 05:05, 21 December 2006 (UTC)
[edit] Lethal
An anonymous editor insists that PNH is life-threatening. I disagree. Parker et al state clearly that there are subclinical variants of PNH, and obviously these are not life-threatening at all. I have asked 84.64.113.176 (talk • contribs) to justify further changes of this kind. JFW | T@lk 22:04, 14 February 2007 (UTC)
[edit] Update
DOI:10.1111/j.1365-2141.2007.06554.x lists a host of symptoms I don't normally associate with PNH. Hoping to get the fulltext to update this article. JFW | T@lk 21:36, 5 April 2007 (UTC)
