Talk:Paroxetine

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Contents 1 Increased Cholesterol & Paroxetine 2 Citation reference 3 Rewrite 4 Any Thoughts? 5 Biased 6 Editing by GSK? 7 Zaps 8 Withdrawal 9 Studies 10 Suicide risks 11 Link to serotonergic 12 Side effects 13 NPOV - let's clean up 14 Paroxetine experience over 12 years of therapy 15 seroxat 16 Warnings 17 Negative side effects 18 Molecular Weight 19 Chemistry Equation To Withdrawal Adverse Experiences (removed***) 20 Codeine and Paroxetine? 21 I am appaled by the quality of this entry 22 Pharmaceutical Assassination

[edit] Increased Cholesterol & Paroxetine

I'm hesitant to edit the article directly as I've no medical background, but I've discovered two studies that indicate Paroxetine can lead to increased cholesterol levels in otherwise healthy patients. This seems an important enough issue to be mentioned here.

[[1]] "Blood samples were collected at baseline, after 8 weeks of paroxetine administration, and post-discontinuation in 18 healthy male volunteers. RESULTS: In the 16 of 18 patients whose plasma levels of paroxetine indicated an unequivocal compliance to treatment, paroxetine administration induced an 11.5% increase in low-density lipoprotein cholesterol (LDL-C), which normalized after paroxetine discontinuation."

[[2]] "We examined serum cholesterol and plasma catecholamine levels in PD before and after paroxetine treatment. The serum cholesterol and plasma catecholamine levels were not different between the PD patients and control subjects before the treatment. However, the levels of total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were significantly increased in the 28 PD patients after 3 months of paroxetine treatment, whereas the body mass index and plasma catecholamine levels were unchanged."

[edit] Citation reference

"Paroxetine is a phenylpiperidine derivative which is chemically unrelated to the tricyclic or tetracyclic antidepressants. In receptor binding studies, paroxetine did not exhibit significant affinity for the adrenergic (α1, α2, β), dopaminergic, serotonergic (5HT1, 5HT2), or histamine receptors of rat brain membrane. A weak affinity for the muscarinic acetylcholine and noradrenaline receptors was evident. The predominant metabolites of paroxetine are essentially inactive as 5-HT reuptake inhibitors." Care to provide citation/reference pls? Uniearth 23:00, 14 November 2006 (UTC)

[edit] Rewrite

This page needs a serious rewrite. Not only does it contain numerous subtle flaws and biased statements, it is generally misleading and strongly worded to dissuade readers against paroxetine's usage. A more thorough, analytical model should be implemented, to better inform of paroxetine's use. I think part of the problem is that there have been too many people posting their own views on this page, and wording them to resemble facts. Wikipedia is not a forum, it's an encyclopedia. And as such, every article needs to be totally unbiased and devoid from any subjective views. --Prisonnet 14:41, 1 November 2006 (UTC)

"Both of the studies concluded that Paxil is significantly more effective than the placebo control group." where is this referenced from? the recent documentary on bbc2 stated that it was no more effective than a placebo, both cannot be right.

It has to be significantly more effective than placebo, or it would not be approved by the FDA and similar drug-monitoring bodies. Sometimes individual studies do not adequately demonstrate or disprove efficacy, which is why repeated studies are done with the largest possible groups. --72.192.118.171 18:06, 8 March 2007 (UTC)

[edit] Any Thoughts?

I realise this isn't a discussion board, but my case seems unusual, particularly as a known side effect of the drug is a reduced sex drive. Anyway, my doctor prescribed me Paxtine (20mg per day paroxetine) as a solution to impotence. I'm just beginning it now - I have a high sex drive/libido naturally, and my problem is most likely anxiety related which this drug is supposed to be able to cure. Just thought it was weird/unusual case. Such a use of the drug certainly isn't mentioned in the article. Any thoughts? (unsigned)

I've also been on Paroxetine, 20mg per day for depression, and I've found my sex drive has increased alot, rather than decreased.. I think that the decreased sex drive can be a side effect of withdrawl, rather than the drug itself. (unsigned)

In the first case, your doctor may feel that a reduced sex drive might actually decrease your anxiety and therefore address the cause of your impotence. In the second case - decreased sex drive can also be a symptom a depression, in which case, getting rid of the depression might improve your response, to the point where the drug's own libido-squashing effect is eclipsed. (I'm not a doctor, but I'm well familiar with Paxil.) 72.70.26.80 11:30, 17 March 2007 (UTC)

[edit] Biased

This page is terribly biased against paxil.

The side-effects, possibilities of suicidal ideation, and withdrawl symptoms (although worse with paxil) are portrayed on this page as only being consequences of taking paxil, whereas all effects of paxil can occur with any ssri.

In addition, these effects of SSRIs are known to be more individual than with most other medications, with some patients receiving absolutely no side effects, and others having numerous ones. This page does not reflect that, but rather implies that all the side effects with occur with everyone taking it.--Prisonnet 20:39, 29 June 2006 (UTC)

- I have taken prozac for 6 months and never felt any discontinuation effect. I have been on paxil for only 4 months and the withdrawal is killing me. I feel and intense electric shock every 5 secs that is sometime intense enough to make me loose balance or have parkinsons disease like body tremors. Paxil withdrawal is HELL, no bias there.

[edit] Editing by GSK?

A suspicious number of the editors of this article have only ever made edits to this article, all of which are edits to make the article more favorable to GSK.

[edit] Zaps

I'm surpised nobody's mentioned the "zaps". The "zaps" are most likely some sort of seizure associated with Paxil withdrawl. They feel like electric shocks inside your head. Many people report them. A simliar condition may result from consumption of MDMA.

True, but its better way to drug yourself than MDMA i think so...

- Paxil withdrawal is real torture. I couldt believe no mentions of the zaps either , thats why i added it. Its not merely "zaps" it really feels like an intense electric shock, intense enough to litteraly throw you off balance or make you have parkinsons disease like body tremors. It is utterly irresponsible for a drug company to market such a drug without telling patients UPFRONT what they are getting into. The withdrawal is 10x more unpleasant than the reasons why i started taking this medicine. Being shy and feeling ackward in social gatherings will feel like a blessing from god once i am trough with the withdrawal... those drugs makers are terrorists, they are torturing me and they actually demanded money for doing so. Incredible... Paxil is the worst drug i have EVER taken, legal or illegal.

[edit] Withdrawal

I know someone who was on Paxil. His doctor switched him over to Effexor, and didn't have him taper off use of Paxil. He didn't notice any withdrawal after he stopped using Paxil.

JesseG 03:32, 2 Jun 2004 (UTC)

Personally, I have been on 150mg a day (Slow Release form) for nearly a year. Didnt notice any real withdrawal after a rather quick stop.

Really? I can't go an 25 or so hours without feeling withdrawl symptoms. The-dissonance-reports 03:56, 12 December 2005 (UTC)

not everyone experiences withdrawal. as stated in the article, about 1/3 of users experience withdrawal, so it's not odd that you might personally know someone who stopped with no problem. but a full third of users experiencing from mild to severe withdrawal is a serious problem, especially in a widely prescribed drug.

I was on a low 25-50 dose for around 6-7 months (I think) and I experienced withdrawal. Shocks, anxiety, strange sounds..etc

I was under Paxil during eight months (20 mg per day), and I ended the treatment cold turkey, so I experienced some withdrawal symptoms like the electric shoks, sweating and headache. This caused me to take the medicine for one more month, but this time I ended the treatment gradually and I experienced no withdrawal symptoms at all. So I think if people inform themselves more about the drug and how they should quit it, all this problem about withdrawal would end.

I have been on Paxil for years and the only reason I'm still on it now is because of "The Zaps". I've tried a few times to just deal with them, but it's really difficult.

I have experienced Paxil withdrawals as well including dizziness, a severe feeling of weakness, and terrible brain "zaps". I'm still cutting down and even just a few mg reduction results in the onset of these symptoms within 36 hours. I was on 20-40 mg for five years and I am now taking 7.5 mg. They initially adminstered the drug to me at age thirteen. I believe more should be said about its use in children and the possiblility of severe withdrawal. I have spoken to people who have experienced permanent gastrointestinal problems because of the drug.

D. Scott 2006-12-13

I've been taking Paxil CR for a while now. I have had the unable to reach orgasm issues as well as the loss of sex drive. The loss of sex drive seems to have gone away, and I find that the frequency that you have intercourse seems to inflate or deflate the affects of the unable to orgasm. The more frequent, the longer it took to reach orgasm, if at all. It was almost like a numbing of the nerves in the genitals, so to speak.

As for withdrawls, I never got the brain zaps, but I do get dizziness and a feeling of disorientation if I forget to take it for over 24 hours, and I get a lesser feeling when I'm trying to cut down the dosage (I went from 50mg of the CR to 25, now back to 50mg). I'm taking it for OCD primarily, and anxiety as a secondary (brought on by the OCD).

[edit] Studies

Whever one says "recent studies have shown," it would be best to give citations, especially when the results are controversial, as any new results concerning a widely-used drug like Paroxetine would be.

I agree, I took the UK form of seroxat for a year and coming off was hell , I cannot comprehend how they can class it as non-addictive, surely when you take another pill to make the side effects go away and therefore chill you out , it is a simple fix, or is it me.

Simply put the drug has a high dependancy on depression and when the user stops , unless supported by another SSRI it will cause all of the above and more in my experience.

[edit] Suicide risks

I was under the impression that the reason the medicine appeared to make people prone to suicide was that the ideation was already there, but they didn't have the energy before to carry out their plans. The medicine gave them that energy to attempt or complete suicide.

JesseG 02:59, Nov 20, 2004 (UTC)

Not true IMHO. My wife was given Seroxat for Post-natal depression. During this period she gained significant body mass (not through eating) and attempted suicide twice. There is no family history or pathological history of this from her.

I can only assume that the drug altered her seratonin levels in a negative fashion and affected thyroid function. Three consultants have concluded that this was not caused by any stress/trauma/post-operative conditions relating to the birth.

Our intention is to sue GSK (who ironically I worked for a few years back) but we are still battling the immediate problems caused by it.

Sorry - i'm not a *registered* wikipedia user.

[edit] Link to serotonergic

I removed the link to serotonergic from the pharmacology section which is currently (probably inappropriately) a redirect to Noradrenergic and specific serotonergic antidepressant. --Overand 00:01, 26 Apr 2005 (UTC)

I've seen it cause a successful suicide. Pharmaceuticals are so synthetic... do YOU know what's in them?

All antidepressants have the potential to incite suicidal ideation. The fact is, they've saved far more lives than they've cost. --Prisonnet 18:08, 8 March 2007 (UTC)

[edit] Side effects

In my case, one of the side effects was weight gain. From a slightly underweight 61kg (at 1.80m) to 70kg. I didn't gain any weight at all in the prior years (took it at age 20-21). Also excessive transpiration seems quite common (at least that's what my psychiatrist told me). This should of course be regarded as purely anecdotal. Personal accounts have reported that this drug has caused blackouts followed by extreme rage.

I believe I am not sleeping well because of this drug. My sleeping patterns have been dramatically effected after starting this medicine. Though I feel better in the day, I'm not sleeping well.

I've had the same issues. I took this medicine when I was 16-18, no side effects until after I got upped to 60 mg. Within two months of upping the dosage, I had gone from 105 pounds to 158 pounds. I quit taking Paxil because the weight gain caused more anxiety and depression than I'd had in the first place, and after quitting the drug, I lost 55 pounds in a matter of three months (with no change in diet or exercise). I'm 20 now, and I've recently gone back on Paxil for panic disorder. Going back on this medicine is so difficult the first few weeks. I can't sleep more than 2 hours at a time, and I'm never hungry anymore, yet I feel energetic. It's worth it to me personally though, because I'd rather have severe insomnia than have panic attacks any time I leave my home. I'd tried psychotherapy, changes in diet, Xanax, and many other things, and Paxil has been the only thing that made any real difference.

[edit] NPOV - let's clean up

This article is poorly written and POV. Rather than primarily informing, it emphasizes controversies without explicitly grounding discussion on credible publied sources and is overly influenced by personal anecdote. A recent retrospective study suggests increased suicide risk results in adults from taking paroxetine.[3] This may well stimulate a flurry of low-quality edits here just when readers will be consulting this article for an "encyclopedic" perspective. Let's clean up our act quickly and have a respectable presentation readied for the onslaught. Myron 06:30, 23 August 2005 (UTC)

The discussion on addiction rests on misapplication of the term and should be eliminated as being misleading. The Wikipedia article provides the currently accepted definition: "uncontrolled, compulsive use despite harm". Paroxetine is not associated with craving and does not produce pleasure or dramatic short-term relief of pain or anxiety. Physical tolerance occurs to certain adverse effects but not to the desired effect (i.e., there is no tachyphylaxis) — the "poop-out" phenomenon is not classified as tolerance — so that another criterion for addiction is not satisfied. Thus addiction is not an issue with paroxetine and does not even deserve mention (any more than one would discuss addiction with regard to aspirin). While physical withdrawal reactions are a major concern with paroxetine, more so than with other serotonin reuptake inhibitor drugs, mention of this belongs under the heading of adverse effects. Myron 07:32, 24 August 2005 (UTC)

Personal accounts have reported that this drug has caused blackouts followed by extreme rage.

This article is not POV. If your concern is that the article is repeating anecdotal information, it warns the reader of that. However, Paxil withdrawal syndrome is not speculation based on a few scattered user reports. It is documented in at least the following journal articles:

Independent Reports: 1993

Is there a serotonergic withdrawal syndrome? Biol Psychiatry 1993;33:851-2. Mallya, White, Gunderson.

Paroxetine (Paxil) "We have received 78 reports of symptoms occurring on withdrawal of paroxetine, including dizziness, sweating, nausea, insomnia, tremor and confusion. Such reactions have been reported more often with paroxetine than with other SSRIs. Reactions tended to start 1-4 days after stopping paroxetine and in several patients resolved on re-instating treatment. Paroxetine should not normally be discontinued abruptly". 1993 Committee on Safety of Medicines & Medicines Control Agency (Great Britain)

1995

Withdrawal syndromes after paroxetine and seatrain discontinuation. J Clin Psychopharmacol. 1995 Oct;15(5):374-5 Fava GA, Grandi S.

A possible paroxetine withdrawal syndrome. Am J Psychiatry. 1995 Apr;152(4):645-6. Phillips.

Paroxetine withdrawal syndrome. Am J Psychiatry. 1995 Jan;152(1):149-50 Pyke.

Potential withdrawal syndrome associated with SSRI discontinuation. Ann Pharmacother. 1995;29:1284-1285. Lazowick, Levin.

1996

More cases of paroxetine withdrawal syndrome. Br J Psychiatry. 1996 Sep;169(3):384. Pacheco, Malo, Aragues, Etxebeste.

Antidepressant withdrawal syndrome. CNS Drugs. 1996;5:278-292. Lejoyeux, Adès, Mourad, Solomon, Dilsaver.

1997

Paroxetine withdrawal syndrome in a neonate. Br J Psychiatry. 1997 Oct;171:391-2 Dahl, Olhager, Ahlner.

Paroxetine discontinuation syndrome in association with sertindole therapy. Br J Psychiatry. 1997 Apr;170:389 Walker-Kinnear, McNaughton.

Antidepressant withdrawal syndrome. Br J Psychiatry. 1997 Mar;170:288 Young, Currie, Ashton.

Newer antidepressants and the discontinuation syndrome. J Clin Psychiatry. 1997;58(suppl 7):17-22. Haddad

Possible biological mechanisms of the serotonin reuptake inhibitor discontinuation syndrome. J Clin Psychiatry. 1997;58(suppl 7):23-27. Schatzberg, Haddad, Kaplan, Lejoyeux, Rosenbaum, Young, et al.

SSRI Withdrawal Syndrome 1997, American Society of Consultant Pharmacists, Inc. Skaehill, Welch

1998

Treatment of disequilibrium and nausea in the SRI discontinuation syndrome. J Clin Psychiatry. 1998 Aug;59(8):431-2 Schechter.

Withdrawal syndrome associated with abrupt discontinuation of SSRIs. J Am Pharm Assoc (Wash). 1998 Jul-Aug;38(4):500-1 Wincor.

Selective serotonin reuptake inhibitor discontinuation syndrome: a randomized clinical trial. Biol Psychiatry. 1998 Jul 15;44(2):77-87 Rosenbaum, Fava, Hoog, Ascroft, Krebs.

Withdrawal syndrome caused by selective serotonin reuptake inhibitors. Schweiz Rundsch Med Prax. 1998;87:345-348 Bryois, Rubin, Zbinden, Baumann.

Selective serotonin reuptake inhibitor discontinuation syndrome: putative mechanisms and prevention strategies. Can J Psychiatry. 1998 Jun;43(5):523-4. Rojas-Fernandez, Gordon.

1999

Selective serotonin reuptake inhibitor discontinuation syndrome: putative mechanisms and prevention strategies. Can J Psychiatry. 1999 Feb;44(1):95-6. Benazzi.

2000

Withdrawal syndrome after the use of serotonin reuptake inhibitors. Tidsskr Nor Laegeforen. 2000 Mar 20;120(8):913-4. Fagan.

Serotonin discontinuation syndrome: does it really exist? W V Med J. 2000 Mar-Apr;96(2):405-7. Nuss, Kincaid.

Paroxetine withdrawal syndrome. Ann Med Interne (Paris). 2000 Apr;151 Suppl A:A52-3. Belloeuf, Le Jeunne, Hugues.

Selective serotonin reuptake inhibitor discontinuation syndrome: proposed diagnostic criteria. J Psychiatry Neurosci. 2000 May;25(3):255-61. Black, Shea, Dursun, Kutcher.

It is serious enough of a concern that it merits more than a mere notation as a "side effect."

I removed the section about "lasting sexual dysfunction." I have never seen a credible source showing permanent, adverse effects of SSRIs. Please, leave the unwarranted claims off of Wikipedia and stick to the science. Furthermore, since when do Paxil withdrawal symptoms last from "months to years?" I believe it's accepted that SSRI Discontinuation Syndrome resolves, at most, after a few weeks without restarting medication. This article certainly needs a clean-up--the author obviously has a strong bias against SSRIs, as also evidenced by condescending language such as, "As soon as you pop a pill..." The "addictive potential" section is especially poorly written. Perhaps the work of Scientologists playing around on Wikipedia? --AJ

Unfortunately, AJ, the "science" must be analyzed for credibility as well. There are few studies showing adverse effects of paroxetine because such studies are not in line with the interests of GlaxoSmithKline. Thus, we need to become competent consumers of research and selectively analyze each research study to see what Pharma connections its authors hold. Additionally, I think the "scientology" comment is out of line; simply because someone does not believe the hype about pharmaceuticals does not make them a scientologist. Your comment is akin to saying that if someone likes fried chicken, they must be black. It's faulty logic like this that leads the world into trouble. -Alex

AJ, you say: "I believe it's accepted that SSRI Discontinuation Syndrome resolves, at most, after a few weeks without restarting medication." I'm sorry, but this is incorrect. Perhaps the reason for the confusion is that persisting adverse effects from previous SSRI use are not the same thing as what is referred to as "discontinuation syndrome". That syndrome is a direct consequence of rapid neurological change from stopping the medication, and yes the obvious symptoms (such as "zaps") generally resolve within a month. Longer-term issues are a consequence of alterations made to the brain during chronic SSRI use (and, especially in the case of paroxetine, the endocrine system), rather than a "withdrawal syndrome" as such. This condition is closer to a post-acute withdrawal syndrome, and is characterised by a non-linear recovery - good "windows" and relapses - and yes, it CAN include sexual dysfunction. It comes with a host of physical symptoms, so has nothing to do with relapse into the original condition. The reason it is underreported is that most long-term SSRI users, faced with post-withdrawal issues, end up back on an SSRI or another psychotropic drug, usually at a doctor's suggestion. As time goes on, and more and more long term SSRI users attempt to cease treatment altogether (either because of poop-out, spiralling side-effects or actual recovery from the initial illness), this condition becomes more common. In 1995, you would have been right to query it, as it was indeed very rare. In 2007, you are somewhat behind the times if you cast doubt on long-term damage from the chronic use of these medications. I do agree that much of the phrasing in this article is very poor and unscientific, but that's a separate issue. And the "scientologist" remark is extraordinarily ignorant. MrBronson 22:02, 22 March 2007 (UTC)

Although things are now more correctly cited, this article is still heavily biased against Paroxetine's use. DirectorStratton 04:30, 1 March 2006 (UTC)

I can't help but wonder how many of the charges of bias are written by GSK or its sockpuppets.

[edit] Paroxetine experience over 12 years of therapy

Paroxetine has allowed me to feel "normal" for the first time in my life. I began taking paroxetine 12 years ago. I started taking 10mg once every day. I now take 25mg CR everyday.

After taking paroxetine for approxinmately 4 years, I tried to taper down and stop taking it. For me, this caused the "zaps" within days. I also had auditory hallucinations, vertigo to the point of not being able to drive or even walk at times and complete loss of libido. Fromj a psychological side, the acute mood swings returned almost immediately as did the depression.

I tapered down over the course of two months with no adjunctive chemical therapy. I continued to see my Psychologist. After four more months of what I experienced as a worsening of my physical and mental conditions and despite continued psychotherapy, I restarted paroxetine with 20mg every day.

Except for the increase in somnolence and returned ejaculatory disability, I returned to "normal". The somnolence passed in about six to eight months. Viagra allowed me to maintain an erection for long enough to have a reasonably normal sex life.

I did try to stop paroxetine therapy once more, about four years ago. Not by choice, but because I lost my medical insurance. At the time, before the patent expired and generic paroxetine was available, it would have cost me over three hundred dollars a month for the medication.

Again, I tapered down over a course of 3 months. Within weeks of decreasing the daily intake, I was acutely unstable physically, mentally and emotionally. This six months was much worse than the earlier attempt and by far worse than I'd been before starting paroxetine therapy. I did continued therapy sessions with a psychologist. For my own sake and that of my family, I began taking paroxetine again.

I can only relate the facts of my own experience. In discussing SSRI treatment with other people that I know who take SSRI's, my experience is not unique.

I will continue to take paroxetine now for two reasons. One, because this particular medication seems to allow my body and brain to act and react in the real world in a more "normal" fashion. Two) because the side effects of not taking it are so debilitating.

To say that a drug makes one behave or think "normally" is close to a contradiction-in-terms in my opinion. It is simply impossible for one to judge the nature of "normal" personal existence as one lacks experience of another individual's subjectivity. Surely you mean that you are placed on a plateau by the drug - it is this "high" which is the reason for your satisfaction and not any imagined normalisation effect. The drug achieves its purpose by reducing the user's consciousness of the moral value of his own actions; he is taken on a rollercoaster ride where his inhibitions are suspended which approaches zombification of the subject. The reason the user persists with the drug is that it makes him less aware of his own identity and ego as does any drug illicit or otherwise. By reducing "anxiety" - which is, after all, a mundane affection - it reduces pain. Of course, the user (and the drug company for that) will try to cover his guilt for enjoying the psychological dissociation by describing the effect as "normalisation"; a conclusion which is clearly absurd. These are a few reflections on the drug from a Freudian perspective. --Nicander 07:34, 13 March 2006 (UTC)

Okay...I agree that Paxil apparently seems to have a big problem with withdrawal effects. However, there are also many ways to get around that, such as switching to Prozac and weaning off of that (whose SSRI discontinuation syndromes are almost non-existent)--there's no reason to simply stay on Paxil forever because of the withdrawal effects. However, it's also possible that the feelings of instability came from returning depressive symptoms (which is likely, given that many mildly depressed people have no trouble weaning off). Your argument about if a person can be more "normal" while taking a medication is a decade-old moral debate that simply doesn't have a clear answer. Just some thoughts/advice, but of course, I'm not a psychiatrist. --AJ

[edit] seroxat

Dont EVER take this drug, my father took 10mg of seroxat for the first time and after 12 hours he tried to kill himself by hanging!!!!!!!!!!!!!!! When my mother found him, she unhooked him from the rope, he was alive, but acted like he was in trance or something (he didnt respond, his eyes were going from left to right). If someone from your family got it prescribed, steal it and burn it, or make sure you watch him day and night.

So, this page is terribly biased against Paxil (Seroxat). GOOD!

I spent nearly eight years in a haze of exhaustion courtesy of this foul drug. The only thing worse than the side effects was trying to withdraw.

In the end I withdrew with the aid of Citalopram but not before my marriage was in tatters and my life nearly ruined.

It's interesting that my G.P. now refuses to prescribe it on the grounds of the side effects and withdrawal symptoms.

There are other, far better anti-depressants on the market. If your doctor does prescribe this for you then please take my advice, rip up the script and find yourself a more enlightened doctor.

I have no axe to grind with GSK. I would like to say this is purely my experience but everyone I know who was prescribed this drug (during the late'90's) experienced a measure of the same side effects and withdrawal problems.

Seroxat? Just don't go there.........

Compliance:

"Paroxetine users should not discontinue and resume treatment with more than a few days' gap between dosings, as paroxetine decreases in effectiveness if it is stopped for a significant amount of time, and then resumed."

I would like a reference for this. Of course effectiveness decreases if you do not take the medication at all. But does it have any long term repercussions?

[edit] Warnings

Everyone who is adding ridiculous warnings about 'birth defects' and such need to stop immediately. Adding this section, besides being biased, is not needed. Paroxetine is in pregnancy category D, so of course it's going to cause birth defects. Just like ibuprofin, aspirin, and warfarin can cause birth defects. The warning already exists in its pregnancy class, it is not appropriate nor necessary to include this section in any medical article of an already pregnancy-scheduled substance. The same applies for suicide warnings. Besides being already stated on the page, all antidepressants already carry this warning.--Prisonnet 18:29, 24 August 2006 (UTC)

[edit] Negative side effects

It has not been mentioned that seroxrat may lead to violent or self harming behaviour that could even be described as physchotic, if you have any worries then contact your GP or primary health care provider, REMEMBER! there is no obligation for you to take an SSRI if you feel that it may not be in your best intrests, it is better to go through a week of cold turkey from this drug than to find yourself under arrest for assault or murder (written by 82.7.91.80, moved by Dirk Beetstra ^{T C} 06:29, 29 August 2006 (UTC))

[edit] Molecular Weight

Although Molecular formula for Paroxetine is given, the informed molecular weigh (374.8) corresponds to Paroxetine Hydrochloride hemihydrate: C19H20FNO3.HCl. 1/2 H2O. Paroxetine (alone) should be 329.37

[edit] Chemistry Equation To Withdrawal Adverse Experiences (removed***)

Hypothesis suggests neuron/receptor damage a more likely cause for suicide than the simple pre-existing suicidal ideation claim and deserves study into consumption and elimination of Fluorine by exact weights of each.

A durable *Teflon like molecule develops from the fluorine-carbon bond in Paroxetine. Certain atoms should not be in the nervous system beyond the blood-brain barrier because they would cause disruption of delicate meninges and receptor damage upon chemical breakdown and synthesis.

The presence of halogens which need only one valence electron to fill their outer electron shells causes an incorrect synthesis, leaving non-transportable molecules to cause what must occur by laws of atomic, chemical and physical properties such as long-term or permanent receptor blocking or burning of delicate meninges by molecular Fluorine.

Not all SSRI compounds contain Fluorine. Prozac has three atoms in contrast to Paxil's one. Fluoxetine is less profitable to Paroxetine, damaging the buyer more quickly. Only natural molecules of carbon hydrogen nitrogen and oxygen are acceptable to the nervous system for normal function**.

Low levels of Seratonin proportionally decrease normal neuronal activity and chemistry in the first instance where an SSRI only magnifies problems.

Low levels of Seratonin have been associated with several disorders, notably depression, migraine, bipolar disorder and anxiety.

Dare we trust what is currently approved? Give some thought to that question before answering. Anyone just reading the facts might become suicidal let alone someone who has been damaged by the very system which causes such extreme societal pressures. Inappropriate trials conducted for cost and gain considerations without regard for the few is or should be well known.

When you fly in first class, it's easy to forget the dots[4]

• Teflon: A carbon-fluorine chain.

• • That no similar and transportable, halogen containing molecules are found in normal and healthy individuals who have never taken such SSRI drugs and the result of the presence of molecular Fluorine supports an acceptable theory.

• • • Citing data from the World Health Organization, "Paxil has the highest incidence rate of withdrawal adverse experiences of any antidepressant drug in the world". Is this not a factual quote?

Given that the recommendation for discontinuation syndrome is factual, I am appalled. Doesn't anyone think for their own self, blindly following such arbitrarily achieved guidelines of a corrupt system. Phenothiazine-derivative drugs are from DuPont introducing Phenothiazine as an insecticide in 1935.

[edit] Codeine and Paroxetine?

I know this isn't really a discussion board, but i've been put on paroxetine in the past few days. Sometimes I get bad headaches, I take an OTC tablet (2) known as nurofen plus (200mb ibuprofen + 12.8mg codeine) which helps a lot. I've heard that Paroxetine actually stops the effects of codeine. Does anyone know much about this, and if it's true, are there any equally effective alternatives for pain relief? Timeshift 12:56, 2 November 2006 (UTC)

Timeshift, I took codeine for a cough while on paroxetine; the codeine didn't work. It actually had a bit of a backwards effect -- it made me hyper. Who knows, though. The folks at www.paxilprogress.org are helpful; perhaps ask them? -- Alex

[edit] I am appaled by the quality of this entry

 The statement:  "In common with previous editions, the programme presented an entirely one-sided picture of events, and could be argued was little more than a television broadcast on behalf of Baum Hedlund, the lawyers acting against GSK" is completely out of place.  The tone used is unprofessional and unfortunate.  It raises the question if the writer is taking parts on this issue.  As stated before, gsk is being sued for millions of dollars over this drug; it is in inappropriate for wikipedia to profess biased opinions about this matter, the drug, the company, or other people involved in this dispute.

[edit] Pharmaceutical Assassination

I will attempt to get USA Today's permission to reprint here.

The dark side of psychiatric drugs - The United States of Violence: A Special Section - Cover Story USA Today (Society for the Advancement of Education), May, 1994 by Tanya Bibeau [5]

Alphaquad 05:18, 7 March 2007 (UTC)