Paracaspase
From Wikipedia, the free encyclopedia
|
mucosa associated lymphoid tissue lymphoma translocation gene 1
|
|
| Identifiers | |
| Symbol | MALT1 MLT |
| HUGO | 6819 |
| Entrez | 10892 |
| OMIM | 604860 |
| RefSeq | NM_173844 |
| UniProt | Q9UDY8 |
| Other data | |
| Locus | Chr. 18 q21 |
Paracaspases (human: MALT1) are related to caspases present in animals and slime mold, in contrast to metacaspases which are present in plants, fungi and "protists".[1]
Paracaspases are more similar to caspases than metacaspases are, indicating that this group of (putative) proteases diverged from caspases from a common metacaspase ancestor. The phylogenetic distribution is a bit confusing, since slime mold diverged earlier than the animal/fungal split.
[edit] References
- ^ Uren A, O'Rourke K, Aravind L, Pisabarro M, Seshagiri S, Koonin E, Dixit V (2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Mol Cell 6 (4): 961-7. PMID 11090634.
