Pamaquine

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Pamaquine
Systematic (IUPAC) name
N,N-diethyl-N'-(6-methoxyquinolin-8-yl)pentane- 1,4-diamine
Identifiers
CAS number	491-92-9
ATC code	?
PubChem	10290
Chemical data
Formula	C₁₉H₂₉N₃O
Mol. mass	315.453 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Pamaquine is an 8-aminoquinoline drug used for the treatment of malaria. It is closely related to primaquine.

1 History
2 Adverse effects
3 Uses
4 Dosing
5 Synonyms
6 References

[edit] History

Pamaquine was the first synthetic antimalarial drug.

[edit] Adverse effects

Like primaquine, pamaquine causes haemolytic anaemia in patients with G6PD deficiency. Patients should therefore always be screened for G6PD deficiency prior to being prescribed pamaquine.

[edit] Uses

Pamaquine is effective against the hypnozoites of the relapsing malarias (P. vivax and P. ovale); and unlike primaquine, it is also very effective against the erythrocytic stages of all four human malarias. One small clinical trial of pamaquine as a causal prophylactic was disappointing^[1] (whereas primaquine is an extremely effective causal prophylactic).

[edit] Dosing

60 mg once daily for 14–21 days.

When treating Plasmodium vivax, an initial course of chloroquine is unnecessary.

[edit] Synonyms

Plasmaquine

[edit] References

^ Sweeney AW, Blackburn CRB, KH Rieckmann. (2004). "Short report: The activity of pamaquine, an 8-aminoquinoline drug, against sporozoite-induced infections of Plasmodium vivax (New Guinea strains)". Am J Trop Med Hyg 71 (2): 187-189.

v • d • e Antimalarial drugs (P01B)
Aminoquinolines	Amodiaquine, Chloroquine, Hydroxychloroquine, Pamaquine, Primaquine
Biguanides	Proguanil, Cycloguanil embolate
Methanolquinolines	Mefloquine, Quinine
Diaminopyridines	Pyrimethamine
Artemisinin derivatives	Artemisinin, Artemether, Artesunate, Artemotil, Artenimol
Others	Halofantrine, Lumefantrine