Palytoxin

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Palytoxin
Formula	C129H223N3O54
Molecular mass	2680.13 amu

Palytoxin is an incredibly complex marine natural product containing 71 stereochemical elements. Palytoxin, isolated from soft coral, is considered to be one of the most toxic non-peptide substances known, second only to Maitotoxin. Professor Yoshito Kishi's group at Harvard University first synthesized palytoxin in 1994. This feat is still considered today by many to be the greatest synthetic accomplishment ever.[1]

Palytoxin targets the sodium-potassium pump protein by binding to the molecule such that the molecule is locked in a position where it allows passive transport of both the sodium and potassium ions, thereby destroying the ion gradient that is essential for most cells.

Typical symptoms of palytoxin poisoning are angina-like chest pains, asthma-like breathing difficulties, tachycardia, unstable blood pressure, hemolysis (destruction of red blood cells), and an electrocardiogram showing an exaggerated T wave. The onset of symptoms is rapid, and death usually follows just minutes after.

Animal studies have shown that vasodilators, such as papverine and isosorbide nitrate, can be used as antidotes. The animal experiments only showed benefit if the antidotes were injected into the heart immediately following exposure.^[1] Treatment in humans is symptomatic and supportive.

[edit] Footnotes

[edit] References

• Nelson, David L. and Cox, Michael M.. "Lehninger Principles of Biochemistry, 4th Edition". Published by Freeman in 2005. p.399 mentions palytoxin.
• Structure of palytoxin (molecule labelled "B")
• CBWInfo