P21
From Wikipedia, the free encyclopedia
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p21WAF/p21CIP
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| Identifiers | |
| Symbol(s) | CDKN1A |
| Entrez | 1026 |
| OMIM | 116899 |
- The correct title of this article is p21. The initial letter is shown capitalized due to technical restrictions.
p21, also known as cyclin-dependent kinase inhibitor 1A or CDKN1A, is a human gene on chromosome 6 (location 6p21.2), that encodes a cyclin-dependent kinase inhibitor that directly inhibits the activity of cyclin-CDK2 and cyclin-CDK4 complexes. p21 functions as a regulator of cell cycle progression at G1 phase[1]. The expression of p21 is controlled by the tumor suppressor protein p53.
The function of this gene relates in part to stress response [2].
p21 is also mediating the resistance of hematopoietic cells to an infection with HIV [3] by complexing with the HIV integrase and thereby aborting chromosomal integration of the provirus.
[edit] External links
[edit] References
- ^ A. L. Gartel and S. K. Radhakrishnan (2005) "Lost in transcription: p21 repression, mechanisms, and consequences" in Cancer Research Volume 65, pages 3980-3985. Entrez PubMed 15899785
- ^ R. Rodriguez and M. Meuth. (2006) "Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress" in Molecular Biology of the Cell Volume 17, pages 402-412. Entrez PubMed 16280359
- ^ Zhang J, Scadden DT, Crumpacker CS.: Primitive hematopoietic cells resist HIV-1 infection via p21. J Clin Invest. 2007 Feb 1;117(2):473-481. PMID 17273559
Cdc2 - Cdc25 - CDK-activating kinase - Cellular apoptosis susceptibility protein - Cyclin (A, B, D, E) - Cyclin-dependent kinase (2, 4, 6) - E2F - Maturation promoting factor - p14arf - p21 - Wee
