P14arf
From Wikipedia, the free encyclopedia
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cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
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| Identifiers | |
| Symbol | CDKN2A CDKN2, MLM |
| HUGO | 1787 |
| Entrez | 1029 |
| OMIM | 600160 |
| RefSeq | NM_000077 |
| UniProt | P42771 |
| Other data | |
| Locus | Chr. 9 p21 |
- The correct title of this article is p14ARF. The initial letter is shown capitalized due to technical restrictions.
p14ARF is an alternate reading frame (ARF) product of the INK4 gene. Both p16INK4a and p14ARF are involved in cell cycle regulation. p14ARF inhibits mdm2, thus promoting p53, which promotes p21 activation, which then binds and inactivates certain cyclin-CDK complexes, which would otherwise promote transcription of genes that would carry the cell through the [[G1/S checkpoint]] of the cell cycle.
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Cdc2 - Cdc25 - CDK-activating kinase - Cellular apoptosis susceptibility protein - Cyclin (A, B, D, E) - Cyclin-dependent kinase (2, 4, 6) - E2F - Maturation promoting factor - p14arf - p21 - Wee
