Talk:P-glycoprotein

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Author writes :

"Increased intestinal expression of P-glycoprotein can reduce the absorption of drugs that are substrates for P-glycoprotein. Thus, there is a reduced bioavailability, therapeutic plasma concentrations are not attained. On the other hand, supratherapeutic plasma concentrations and drug toxicity may result because of decreased P-glycoprotein expression Active cellular transport of antineoplastics resulting in multidrug resistance to these drugs"

I'm unclear on this, but if the P-gp is pumping the substance out of the cell, then wouldn't PLASMA concentrations GO UP (not down) ? Eg. would the problem be that there's PLENTY (or too much) medication in the Plasma, and TOO LITTLE in the Target Tissue (eg. inside the cells) ?

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