Orthostatic intolerance
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Orthostatic intolerance is the failure of the body to properly adjust to an upright position, especially with respect to blood flow, heart rate, and blood pressure.
A common manifestation of chronic orthostatic intolerance is postural orthostatic tachycardia syndrome.
Orthostatic intolerance may result from crippled norepinephrine receptors that lack the ability to receive norepinephrine. Norepinephrine is one of many chemicals that help to control blood pressure.
The loss of orthostatic tolerance is also an undesirable consequence of human adaptation to space and has often been emulated in head-down bed rest studies.
A notable sufferer is Greg Page, formerly of The Wiggles. It is due to this illness that Page chose to leave the group.
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