Noxa
From Wikipedia, the free encyclopedia
| phorbol-12-myristate-13-acetate-induced protein 1 | |
|---|---|
| Symbol(s): | PMAIP1 |
| Other names: | APR, NOXA |
| Genetic data | |
| Locus: | Chr. 18 q21.32 |
| Database Links | |
| Entrez: | 5366 |
| OMIM: | 604959 |
| RefSeq: | NM_021127 |
| UniProt: | Q13794 |
Noxa (Latin for damage) is a pro-apoptotic member of the Bcl-2 protein family.[1] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor p53, and Noxa has been shown to be involved in p53-mediated apoptosis.
[edit] See also
- Apoptosis
- Apoptosome
- Bcl-2
- Bcl-2-associated_X_protein (BAX)
- BH3 interacting domain death agonist (BID)
- Caspases
- Cytochrome c
- Mitochondrion
- p53 upregulated modulator of apoptosis (PUMA)
[edit] References
- ^ Oda, E.; Ohki R., Murasawa H., Nemoto J., Shibue T., Yamashita T., Tokino T., Taniguchi T. and Tanaka N. (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science 288: 1053-1058.
