Talk:NF-kB
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Question - Is there a tumor with NF-KB and Ubiquitin affected?
I'm not sure what you mean, can you be more specific? By "Ubiquitin" do you mean the protein or the pathway?
Also, in your section on NF-kB and cancer, you state, "When NF-κB becomes mutated such that the cell proliferation pathway is constitutively activated, the cells in which NF-κB is mutated may readily spiral down into uncontrolled proliferation, a hallmark of tumors." While it's possible this happens in some cases (though I'm not aware of any), the typical case is that NF-kB family members are amplified or rearranged; while one could think of these as mutations, we typically don't, we think of them as amplification and rearrangement. NF-kB signaling can also be upregulated by oncogenes, the classic case being Ras and Raf (though I can't recall the reference). Another well-known oncogene is Her2/Neu, a significant player in breast cancer, which activates Akt, leading to activation of NF-kB-dependent gene expression. There may also be a role for IkB inhibition in the upregulation of NF-kB in cancer, but nothing specific comes to mind.
All that said, this is a tough article to write, and you've done a great job--much better than I could have done. :) ~Doc~ EquationDoc 04:05, 12 November 2006 (UTC)
[edit] Unspecific references
I moved the following refereneces, that doesn't seem to be cited in the main text. Please reintroduce them if appropriate...:
[1] Shehata M, Rel/Nuclear factor-kappaB apoptosis pathways in human cervical cancer cells, Cancer Cell International 2005, 5; 10.
[2] Lindström MT, Bennet R Philip, The role of nuclear factor kappaB in human labor. Reproduction (2005) 130: 569-581.
[3] Buss H, Dörrie A, Schmitz M, Lienhard M, Hoffman E, Resh K, Constitutive and Interleukin-1-inducible Phosphoryltion of p65 NF-κB at Serine 536 Is Mediated by Multiple Protein Kinases Including IκB Kinase (IKK)-α ,IKKβ, IKKЄ, TRAF Family Member-associated (TANK)-binding Kinase 1 (TBK1), and an Unknown Kinase and Couples p65 to TATA-binding Protein-associated Factor II31-mediated Interleukin-8 Transcription. Journal of Biological Chemistry 2000; 279 (53): 55633-55643.
[4] Barnes, Peter J., Karin, Michael. Nuclear Factor-κB -- A Pivotal Transcription Factor in Chronic Inflammatory Diseases. New England Journal of Medicine 1997; 336: 1066-1071
[5] Gilmore, Thomas D. (editor). NF-κB: From Basic Research to Human Disease. Oncogene Oct 2006; 25 (51): 6679 - 6899
Kjaergaard 09:35, 21 January 2007 (UTC)
