Neurotensin
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neurotensin
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| Identifiers | |
| Symbol | NTS |
| HUGO | 8038 |
| Entrez | 4922 |
| OMIM | 162650 |
| RefSeq | NM_006183 |
| UniProt | P30990 |
| Other data | |
| Locus | Chr. 12 q21 |
Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system. Neurotensin is synthesized as part of a 169-170 amino acid precursor protein that also contains the related neuropeptide neuromedin N (Dobner, P.R., Barber, D.L., Villa-Komaroff, L., and McKiernan, C. Proc. Natl. Acad. Sci. USA Vol. 84, 3516-3520; Kislauski, E., Bullock, B., McNeil, S., and Dobner, P.R. J. Biol. Chem. 263, 4963-4968). The peptide coding domains are located in tandem near the carboxyl terminal end of the precursor and are bounded and separated by paired basic amino acid (lysine-arginine) processing sites.
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Angiotensin - Bombesin - Bradykinin - Calcitonin - Calcitonin gene-related peptide - Carnosine - Cholecystokinin - Delta sleep-inducing peptide - FMRFamide - Galanin - Gastric inhibitory polypeptide - Gastrin releasing peptide - Gastrin - Motilin - Neuromedin B - Neuropeptide Y - Neurophysins - Neurotensin - Opioid peptide - Pancreatic polypeptide - Pituitary adenylate cyclase activating peptide - Secretin - Tachykinins - Vasoactive intestinal peptide - Vasopressin
Hypothalamic: Somatostatin - CRH - GnRH - GHRH - Orexins - TRH - POMC (ACTH, MSH, Lipotropin)
