Neuronal calcium sensor

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Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin, GCAP, neurocalcin, visinin etc. All the members carry 4 EF hand motifs (out of which only 2 or 3 bind calcium) and an N-myristoyl group. ^[1].

[edit] Members of NCS family

• NCS1 (Frequenin)
• visinin
• VILIP-1 (Visinin-like-protein-1)
• hippocalcin
• recoverin
• GCAP
• neurocalcin
• visinin
• Potassium Channel interacting proteins (KChIPs 1-4), including:

- Calsenilin or DREAM/KChIP-3 (downstream regulatory element antagonist modulator/potassium channel interacting protein) - Calsenilin like protein (KChIP-4)

[edit] References

1. ^ Robert D. Burgoyne , Dermott W. O'Callaghan , Burcu Hasdemir , Lee P. Haynes and Alexei V. Tepikin, Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function, Trends in Neurosciences, Volume 27, Issue 4, , April 2004, Pages 203-209. (http://www.sciencedirect.com/science/article/B6T0V-4BMJWW0-1/2/379a2db07be2abda2f33892ef52bbf25)