Neuroglobin

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Neuroglobin
Identifiers
Symbol NGB
HUGO 6553
Entrez 58157
OMIM 605304
UniProt Q9NPG2
Other data
Locus Chr. 14 q24


Neuroglobin is a member of the vertebrate globin family involved in cellular oxygen homeostasis. It is an intracellular hemoprotein expressed in the central and peripheral nervous system, cerebrospinal fluid, retina and endocrine tissues. Neuroglobin is a monomer that reversibly binds oxygen with an affinity higher than that of hemoglobin. It also increases oxygen availability to brain tissue and provides protection under hypoxic or ischemic conditions, potentially limiting brain damage. It is of ancient evolutionary origin, and is homologous to nerve globins of invertebrates.

Neuroglobin was first identified by Thorsten Burmester et al. in 2000[1].

[edit] See also


[edit] Note

  1. ↑ Burmester, T.; Weich, B.; Reinhardt, S.; Hankeln, T. A vertebrate globin expressed in the brain. Nature 407: 520-523, 2000.
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