Nebulin
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nebulin
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| Identifiers | |
| Symbol | NEB NEM2 |
| HUGO | 7720 |
| Entrez | 4703 |
| OMIM | 161650 |
| RefSeq | NM_004543 |
| UniProt | P20929 |
| Other data | |
| Locus | Chr. 2 q22 |
Nebulin is an actin-binding protein which is localized to the I-band in skeletal muscle. It is a very large protein (600-900 kDa) and binds as many as 200 actin monomers. Its length is proportional to thin filament length.
The interaction of nebulin with actin is Calcium-Calmodulin sensitive.
Mutations in nebulin cause some cases of the autosomal recessive disorder nemaline myopathy.
[edit] External links
Microfilaments: Actins - Myosins - Actin-binding proteins
Intermediate filaments: type 1 and 2 Cytokeratin (type I, type II)
type 3 Desmin, GFAP, Peripherin, Vimentin
type 4 Internexin, Nestin, Neurofilament
type 5 Lamin (A, B)
Microtubules: Dyneins - Kinesins - MAPs (Tau protein) - Tubulins
Prokaryotic cytoskeleton: Crescentin - FtsZ - MreB
Other: Major Sperm Proteins
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