NBQX

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NBQX (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione) is an AMPA receptor antagonist. Brown/Red powder.

Disodium salt version can be dissolved in water at higher concentrations (<30 mM).

Blocks AMPA receptors in micromolar concentrations (~10–20 μM) and also kainate receptors. In experiments it is used to counter glutamate excitotoxicity.[1]

[edit] References

  1. ^ Pitt, D.; Werner, P.; Raine, C. S. (2000). "Glutamate excitotoxicity in a model of multiple sclerosis". Nat Med. 6 (1): 67–70.
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